TY - JOUR
T1 - Sperm donation perinatal outcomes in an Australian population cohort
AU - Adams, Damian
AU - Fernandez, Renae
AU - Moore, Vivienne
AU - Willson, Kristyn
AU - Rumbold, Alice
AU - de Lacey, Sheryl
AU - Scheil, Wendy
AU - Davies, Michael
PY - 2017/12
Y1 - 2017/12
N2 - Aim: To compare perinatal outcomes for neonates conceived with donated sperm with those for neonates conceived spontaneously in an Australian population cohort. Methods: Perinatal outcomes for all births in South Australia for the period January 1986–December 2002 were linked with assisted reproductive treatment records to determine those conceived from donated sperm. Birth outcome measures were analyzed using Student's t-test and logistic regression using generalized estimating equations to determine statistical significance. Results: Donor sperm neonates were not significantly different from their spontaneously conceived counterparts in terms of mean birthweight, low birthweight, preterm delivery, small for gestational age, or large for gestational age. They were, however, significantly more likely to be born at lower mean gestational age (P = 0.012), and to have preterm delivery with low birthweight (P = 0.008), when controlling for maternal age, parity, ethnicity, socioeconomic quartile and baby's sex. These associations were not apparent when singletons and twins were considered separately. Conclusion: There was some evidence of compromised perinatal outcomes for donor sperm neonates compared with their spontaneously conceived counterparts, which appeared to be partly attributable to multiplicity.
AB - Aim: To compare perinatal outcomes for neonates conceived with donated sperm with those for neonates conceived spontaneously in an Australian population cohort. Methods: Perinatal outcomes for all births in South Australia for the period January 1986–December 2002 were linked with assisted reproductive treatment records to determine those conceived from donated sperm. Birth outcome measures were analyzed using Student's t-test and logistic regression using generalized estimating equations to determine statistical significance. Results: Donor sperm neonates were not significantly different from their spontaneously conceived counterparts in terms of mean birthweight, low birthweight, preterm delivery, small for gestational age, or large for gestational age. They were, however, significantly more likely to be born at lower mean gestational age (P = 0.012), and to have preterm delivery with low birthweight (P = 0.008), when controlling for maternal age, parity, ethnicity, socioeconomic quartile and baby's sex. These associations were not apparent when singletons and twins were considered separately. Conclusion: There was some evidence of compromised perinatal outcomes for donor sperm neonates compared with their spontaneously conceived counterparts, which appeared to be partly attributable to multiplicity.
KW - donor conception
KW - infant
KW - insemination artificial
KW - population
KW - spermatozoa
UR - http://www.scopus.com/inward/record.url?scp=85038571243&partnerID=8YFLogxK
U2 - 10.1111/jog.13449
DO - 10.1111/jog.13449
M3 - Article
VL - 43
SP - 1830
EP - 1839
JO - JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
JF - JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
SN - 1341-8076
IS - 12
ER -