Sphingosine kinase (SphK) mediates transactivation of the epidermal growth factor receptor (EGFR) by estrogen in breast cancer cells

Olga Sukocheva; Carol Wadham; Andrew James Holmes; Mathew Vadas

Sphingosine kinase (SphK) mediates transactivation of the epidermal growth factor receptor (EGFR) by estrogen in breast cancer cells

Olga Sukocheva, Carol Wadham, Andrew James Holmes, Mathew Vadas

College of Nursing and Health Sciences

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

Our data demonstrate that E2-induced EGFR transactivation is mediated by Edg-3 via activation of the SphK/S1P pathway. This indicates that a given GPCR ligand (i.e., S1P) dependent transactivation of EGFR can be activated by another independent ligand (i.e., estrogen), suggesting a new model of signal transactivation between three individual ligand-receptor systems.( Cancer Research, April 2006 Volume 66, Issue 8 Supplement, Abstract 2935).

Original language	English
Number of pages	1
Journal	Cancer Research
Volume	66
Issue number	8
Publication status	Published - 7 Apr 2006

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title = "Sphingosine kinase (SphK) mediates transactivation of the epidermal growth factor receptor (EGFR) by estrogen in breast cancer cells",

abstract = "Our data demonstrate that E2-induced EGFR transactivation is mediated by Edg-3 via activation of the SphK/S1P pathway. This indicates that a given GPCR ligand (i.e., S1P) dependent transactivation of EGFR can be activated by another independent ligand (i.e., estrogen), suggesting a new model of signal transactivation between three individual ligand-receptor systems.( Cancer Research, April 2006 Volume 66, Issue 8 Supplement, Abstract 2935).",

author = "Olga Sukocheva and Carol Wadham and Holmes, {Andrew James} and Mathew Vadas",

year = "2006",

month = apr,

day = "7",

language = "English",

volume = "66",

journal = "Cancer Research",

issn = "0008-5472",

publisher = "American Association for Cancer Research",

number = "8",

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TY - JOUR

T1 - Sphingosine kinase (SphK) mediates transactivation of the epidermal growth factor receptor (EGFR) by estrogen in breast cancer cells

AU - Sukocheva, Olga

AU - Wadham, Carol

AU - Holmes, Andrew James

AU - Vadas, Mathew

PY - 2006/4/7

Y1 - 2006/4/7

N2 - Our data demonstrate that E2-induced EGFR transactivation is mediated by Edg-3 via activation of the SphK/S1P pathway. This indicates that a given GPCR ligand (i.e., S1P) dependent transactivation of EGFR can be activated by another independent ligand (i.e., estrogen), suggesting a new model of signal transactivation between three individual ligand-receptor systems.( Cancer Research, April 2006 Volume 66, Issue 8 Supplement, Abstract 2935).

AB - Our data demonstrate that E2-induced EGFR transactivation is mediated by Edg-3 via activation of the SphK/S1P pathway. This indicates that a given GPCR ligand (i.e., S1P) dependent transactivation of EGFR can be activated by another independent ligand (i.e., estrogen), suggesting a new model of signal transactivation between three individual ligand-receptor systems.( Cancer Research, April 2006 Volume 66, Issue 8 Supplement, Abstract 2935).

M3 - Meeting Abstract

SN - 0008-5472

VL - 66

JO - Cancer Research

JF - Cancer Research

IS - 8

ER -

Sphingosine kinase (SphK) mediates transactivation of the epidermal growth factor receptor (EGFR) by estrogen in breast cancer cells

Abstract

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