Spinal cord serotonin release and raised blood pressure after brainstem kainic acid injection

P. M. Pilowsky; V. Kapoor; J. B. Minson; M. J. West; J. P. Chalmers

doi:10.1016/0006-8993(86)91318-1

Spinal cord serotonin release and raised blood pressure after brainstem kainic acid injection

P. M. Pilowsky, V. Kapoor, J. B. Minson, M. J. West, J. P. Chalmers

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

The recently developed technique of in vivo dialysis has permitted us to make direct measurements of serotonin release in a specific region of the spinal cord and to relate this to changes in blood pressure elicited by chemical stimulation of the brainstem. In the present experiments we have shown that chemical stimulation of bulbospinal neurons in the region of the B3 cell group in the ventromedial medulla, causes an increase in the release of serotonin in the thoracic spinal cord and that this release is associated with an increase in blood pressure.

Original language	English
Pages (from-to)	354-357
Number of pages	4
Journal	Brain Research
Volume	366
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(86)91318-1
Publication status	Published - 26 Feb 1986

Keywords

bulbospinal serotonin neuron
in vivo brain dialysis
sympathetic activity
ventrolateral medulla

Access to Document

10.1016/0006-8993(86)91318-1Licence: In Copyright

Cite this

@article{df06336803e041b3a132ef89dbfa8a87,

title = "Spinal cord serotonin release and raised blood pressure after brainstem kainic acid injection",

abstract = "The recently developed technique of in vivo dialysis has permitted us to make direct measurements of serotonin release in a specific region of the spinal cord and to relate this to changes in blood pressure elicited by chemical stimulation of the brainstem. In the present experiments we have shown that chemical stimulation of bulbospinal neurons in the region of the B3 cell group in the ventromedial medulla, causes an increase in the release of serotonin in the thoracic spinal cord and that this release is associated with an increase in blood pressure.",

keywords = "bulbospinal serotonin neuron, in vivo brain dialysis, sympathetic activity, ventrolateral medulla",

author = "Pilowsky, {P. M.} and V. Kapoor and Minson, {J. B.} and West, {M. J.} and Chalmers, {J. P.}",

year = "1986",

month = feb,

day = "26",

doi = "10.1016/0006-8993(86)91318-1",

language = "English",

volume = "366",

pages = "354--357",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Spinal cord serotonin release and raised blood pressure after brainstem kainic acid injection

AU - Pilowsky, P. M.

AU - Kapoor, V.

AU - Minson, J. B.

AU - West, M. J.

AU - Chalmers, J. P.

PY - 1986/2/26

Y1 - 1986/2/26

N2 - The recently developed technique of in vivo dialysis has permitted us to make direct measurements of serotonin release in a specific region of the spinal cord and to relate this to changes in blood pressure elicited by chemical stimulation of the brainstem. In the present experiments we have shown that chemical stimulation of bulbospinal neurons in the region of the B3 cell group in the ventromedial medulla, causes an increase in the release of serotonin in the thoracic spinal cord and that this release is associated with an increase in blood pressure.

AB - The recently developed technique of in vivo dialysis has permitted us to make direct measurements of serotonin release in a specific region of the spinal cord and to relate this to changes in blood pressure elicited by chemical stimulation of the brainstem. In the present experiments we have shown that chemical stimulation of bulbospinal neurons in the region of the B3 cell group in the ventromedial medulla, causes an increase in the release of serotonin in the thoracic spinal cord and that this release is associated with an increase in blood pressure.

KW - bulbospinal serotonin neuron

KW - in vivo brain dialysis

KW - sympathetic activity

KW - ventrolateral medulla

UR - http://www.scopus.com/inward/record.url?scp=0022633431&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(86)91318-1

DO - 10.1016/0006-8993(86)91318-1

M3 - Article

C2 - 3697690

AN - SCOPUS:0022633431

SN - 0006-8993

VL - 366

SP - 354

EP - 357

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Spinal cord serotonin release and raised blood pressure after brainstem kainic acid injection

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this