StrataXRT for the prevention and treatment of radiation dermatitis: a critical review

Milena Gojsevic, Shereen Akkila, Samantha K.F. Kennedy, Patries Herst, Mami Ogita, Jason C. Ye, Saba Shariati, Thenugaa Rajeswaran, Tara Behroozian, Shing Fung Lee, Raymond J. Chan, Edward Chow

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose: The primary objective is to systematically review primary studies, such as randomized control trials (RCTs), feasibility, exploratory, and case studies; and the secondary objective is to evaluate all secondary articles, such as reviews, guidelines, and editorials, relevant to the use of StrataXRT for the prevention and/or management of radiation dermatitis (RD) in cancer patients. 

Methods: A literature search was conducted up to February 26, 2023, for articles investigating the use of StrataXRT for the prevention and treatment of RD, in the following databases: Ovid MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Google Scholar. The keywords “StrataXRT”, “dermatitis”, “radiotherapy”, and “radiation” were used to identify relevant articles. 

Results: Twenty-seven articles from 2018 to 2022 were identified to fulfill the inclusion criteria of this review, of which nine are primary studies and 18 are secondary papers. Significant heterogeneity was observed in the current literature studying the effects of StrataXRT, making it difficult to make cross-trial comparisons. There is a suggestion of the efficacy of StrataXRT in the prevention and treatment of RD. 

Conclusion: The findings of this review recommend further adequately powered RCTs with robust methodology including patient and clinician assessments to determine the efficacy of StrataXRT in preventing and treating RD. This is essential to improve the quality of life of patients and identify which groups of patients would benefit most from StrataXRT.

Original languageEnglish
Article number713
Number of pages20
JournalSupportive Care in Cancer
Volume31
Issue number12
Early online date21 Nov 2023
DOIs
Publication statusPublished - Dec 2023

Keywords

  • Patient-reported outcome
  • Radiation dermatitis
  • Review
  • Skin toxicity
  • StrataXRT

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