Stress and Programming of Metabolic Disease

Song Zhang, Shervi Lie, Lisa Nicholas, Leewen Rattanatray, Janna Morrison, I Caroline McMillen

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


    It has been proposed that the developmental programming of the hypothalamopituitary-adrenocortical (HPA) axis is a conserved evolutionary response to a suboptimal early environment which originates in the embryo, fetus or neonate and which persists into postnatal life in anticipation of a life of adversity (Worthman and Kuzara, 2005). Such a programmed response may result in an increased stress responsiveness and hypercortisolism in postnatal life and may in turn exacerbate the metabolic and cardiovascular sequelae of a poor early environment which include central obesity, insulin resistance, glucose intolerance and hypertension (Barker and Osmond, 1986, Barker et al., 1989, McMillen and Robinson, 2005, Phillips, 2007).

    Original languageEnglish
    Title of host publicationStress and Developmental Programming of Health and Disease
    Subtitle of host publicationBeyond Phenomenology
    PublisherNova Science Publisher, Inc
    Number of pages44
    ISBN (Electronic)9781634633703
    ISBN (Print)9781633218369
    Publication statusPublished - 1 Oct 2014


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