Stress and Programming of Metabolic Disease

Song Zhang; Shervi Lie; Lisa Nicholas; Leewen Rattanatray; Janna Morrison; I Caroline McMillen

Stress and Programming of Metabolic Disease

Song Zhang, Shervi Lie, Lisa Nicholas, Leewen Rattanatray, Janna Morrison, I Caroline McMillen

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

It has been proposed that the developmental programming of the hypothalamopituitary-adrenocortical (HPA) axis is a conserved evolutionary response to a suboptimal early environment which originates in the embryo, fetus or neonate and which persists into postnatal life in anticipation of a life of adversity (Worthman and Kuzara, 2005). Such a programmed response may result in an increased stress responsiveness and hypercortisolism in postnatal life and may in turn exacerbate the metabolic and cardiovascular sequelae of a poor early environment which include central obesity, insulin resistance, glucose intolerance and hypertension (Barker and Osmond, 1986, Barker et al., 1989, McMillen and Robinson, 2005, Phillips, 2007).

Original language	English
Title of host publication	Stress and Developmental Programming of Health and Disease
Subtitle of host publication	Beyond Phenomenology
Publisher	Nova Science Publisher, Inc
Pages	87-130
Number of pages	44
ISBN (Electronic)	9781634633703
ISBN (Print)	9781633218369
Publication status	Published - 1 Oct 2014

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AU - Lie, Shervi

AU - Nicholas, Lisa

AU - Rattanatray, Leewen

AU - Morrison, Janna

AU - McMillen, I Caroline

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AB - It has been proposed that the developmental programming of the hypothalamopituitary-adrenocortical (HPA) axis is a conserved evolutionary response to a suboptimal early environment which originates in the embryo, fetus or neonate and which persists into postnatal life in anticipation of a life of adversity (Worthman and Kuzara, 2005). Such a programmed response may result in an increased stress responsiveness and hypercortisolism in postnatal life and may in turn exacerbate the metabolic and cardiovascular sequelae of a poor early environment which include central obesity, insulin resistance, glucose intolerance and hypertension (Barker and Osmond, 1986, Barker et al., 1989, McMillen and Robinson, 2005, Phillips, 2007).

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BT - Stress and Developmental Programming of Health and Disease

PB - Nova Science Publisher, Inc

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