Structural diversity and chemical synthesis of peroxide and peroxide-derived polyketide metabolites from marine sponges

Matthew Norris, Michael Perkins

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    Covering: up to early 2016 Marine sponges are widely known as a rich source of natural products, especially of polyketide origin, with a wealth of chemical diversity. Within this vast collection, peroxide and peroxide-derived secondary metabolites have attracted significant interest in the fields of natural product isolation and chemical synthesis for their structural distinction and promising in vitro antimicrobial and anticancer properties. In this review, peroxide and peroxide-derived polyketide metabolites isolated from marine sponges in the past 35 years are summarised. Efforts toward their synthesis are detailed with a focus on methods that utilise or attempt to elucidate the complex biosynthetic interrelationships of these compounds beyond enzymatic polyketide synthesis. Recent isolations, advances in synthetic methodology and theories of biogenesis are highlighted and critically evaluated.

    Original languageEnglish
    Pages (from-to)861-880
    Number of pages20
    JournalNatural Product Reports
    Volume33
    Issue number7
    DOIs
    Publication statusPublished - 2016

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