Structure and function of the thermoTRP channel pore

Jie Zheng, Linlin Ma

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    22 Citations (Scopus)

    Abstract

    Temperature-sensitive transient receptor potential (TRP) channels are structurally similar to other tetrameric cation channels, but can be potently activated by heat. Recent studies suggest that the pore-forming region directly participates in activation gating. In this chapter, we summarize major findings from both structural and functional studies concerning the gating role of the pore region, focusing in particular on TRPV1. The emerging picture is that the peripheral S1-S4 region of TRPV1 is rigid and plays a supporting role for thepore to undergo conformational rearrangements. This places the pore region in the center of activation gating.

    Original languageEnglish
    Title of host publicationThermal Sensors
    PublisherAcademic Press
    Pages233-257
    Number of pages25
    Volume74
    Edition1
    ISBN (Print)9780128001813
    DOIs
    Publication statusPublished - 2014

    Publication series

    NameCurrent Topics in Membranes
    Number1
    Volume74
    ISSN (Print)1063-5823

    Keywords

    • Allosteric coupling
    • Conformational rearrangement
    • Structure-function relationship
    • Temperature-sensing

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