Subpopulations of neurons in the guinea-pig inferior mesenteric ganglia distinguished by the differential distribution of neurofilament triplet epitopes

James C. Vickers, Marcello Costa

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    The distribution of the neurofilament protein triplet was examined in neurochemically identified subpopulations of neurons in the guinea-pig inferior mesenteric ganglion. A majority of the catecholamine-containing nerve cell bodies also contained the neurofilament protein triplet. However, a major proportion of the noradrenergic, neuropeptide Y-immunoreactive neurons did not contain neurofilament protein triplet immunoreactivity. Furthermore, a specific subpopulation of neurons that lacked catecholamines and were associated with the hypogastric nerve could be distinguished by the unusual feature of cell body content of post-translationally modified neurofilament protein triplet epitopes. These studies indicate that neurons in the inferior mesenteric ganglia can be distinguished by the presence of specific neurofilament protein triplet epitopes, and thus this class of intermediate filament proteins may confer specific properties to the neurons in which it is contained.

    Original languageEnglish
    Pages (from-to)417-426
    Number of pages10
    JournalJournal of Chemical Neuroanatomy
    Volume5
    Issue number5
    DOIs
    Publication statusPublished - Sep 1992

    Keywords

    • Inferior mesenteric ganglia
    • Neurofilament
    • Phosphorylation
    • Prevertebral sympathetic ganglia

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