TY - JOUR
T1 - Subpopulations of neurons in the guinea-pig inferior mesenteric ganglia distinguished by the differential distribution of neurofilament triplet epitopes
AU - Vickers, James C.
AU - Costa, Marcello
PY - 1992/9
Y1 - 1992/9
N2 - The distribution of the neurofilament protein triplet was examined in neurochemically identified subpopulations of neurons in the guinea-pig inferior mesenteric ganglion. A majority of the catecholamine-containing nerve cell bodies also contained the neurofilament protein triplet. However, a major proportion of the noradrenergic, neuropeptide Y-immunoreactive neurons did not contain neurofilament protein triplet immunoreactivity. Furthermore, a specific subpopulation of neurons that lacked catecholamines and were associated with the hypogastric nerve could be distinguished by the unusual feature of cell body content of post-translationally modified neurofilament protein triplet epitopes. These studies indicate that neurons in the inferior mesenteric ganglia can be distinguished by the presence of specific neurofilament protein triplet epitopes, and thus this class of intermediate filament proteins may confer specific properties to the neurons in which it is contained.
AB - The distribution of the neurofilament protein triplet was examined in neurochemically identified subpopulations of neurons in the guinea-pig inferior mesenteric ganglion. A majority of the catecholamine-containing nerve cell bodies also contained the neurofilament protein triplet. However, a major proportion of the noradrenergic, neuropeptide Y-immunoreactive neurons did not contain neurofilament protein triplet immunoreactivity. Furthermore, a specific subpopulation of neurons that lacked catecholamines and were associated with the hypogastric nerve could be distinguished by the unusual feature of cell body content of post-translationally modified neurofilament protein triplet epitopes. These studies indicate that neurons in the inferior mesenteric ganglia can be distinguished by the presence of specific neurofilament protein triplet epitopes, and thus this class of intermediate filament proteins may confer specific properties to the neurons in which it is contained.
KW - Inferior mesenteric ganglia
KW - Neurofilament
KW - Phosphorylation
KW - Prevertebral sympathetic ganglia
UR - http://www.scopus.com/inward/record.url?scp=0026674333&partnerID=8YFLogxK
U2 - 10.1016/0891-0618(92)90058-X
DO - 10.1016/0891-0618(92)90058-X
M3 - Article
C2 - 1384556
AN - SCOPUS:0026674333
SN - 0891-0618
VL - 5
SP - 417
EP - 426
JO - Journal of Chemical Neuroanatomy
JF - Journal of Chemical Neuroanatomy
IS - 5
ER -