Substance p and serotonergic inputs to sympathetic preganglionic neurons

P. M. Pilowsky, I. J. Llewellyn-Smith, J. B. Minson, L. F. Arnolda, J. P. Chalmers

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    9 Citations (Scopus)


    Sympathetic preganglionic neurons are the final central links in the sympathetic pathways that control the heart and blood vessels. The neurotransmitters present in the supraspinal pathways that control the activity of sympathetic preganglionic neurons include amino acids, amines and peptides. In this paper we discuss evidence that suggests a role for serotonin and substance P in these pathways. Both of these neurotransmitters are present in bulbospinal neurons. Our results suggest that they have an important physiological role in the central regulation of blood pressure.

    Original languageEnglish
    Pages (from-to)335-344
    Number of pages10
    JournalClinical and Experimental Hypertension
    Issue number1-2
    Publication statusPublished - 1995


    • Blood Pressure
    • Intracellular
    • Ultrastructure
    • Vasoconstrictor


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