Substance P immunoreactive sensory nerves supply the rat iris and cornea

A. Miller, M. Costa, J. B. Furness, I. W. Chubb

    Research output: Contribution to journalArticle

    110 Citations (Scopus)

    Abstract

    The presence, distribution and origin of substance P immunoreactive axons in the rat iris and cornea were investigated in whole mount preparations. A dense network of substance P immunoreactive was found throughout the iris but not in the ciliary body. In the cornea, substance P immunoreactive axons were found in the substantia propria, in the subepithelial layer and in the corneal epithelium. Following electrocoagulation of the opthalmic nerve, most of the substance P immunoreactive axons in the iris and cornea disappeared. No changes in the substance P immunoreactive axons occurred after removal of the superior cervical ganglion. It is concluded that the iris and the cornea are supplied by sensory nerves containing substance P immunoreactivity.

    Original languageEnglish
    Pages (from-to)243-249
    Number of pages7
    JournalNeuroscience letters
    Volume23
    Issue number3
    DOIs
    Publication statusPublished - 29 May 1981

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