Substrate independent silver nanoparticle based antibacterial coatings

Shima Taheri, Alex Cavallaro, Susan N. Christo, Louise E. Smith, Peter Majewski, Mary Barton, John D. Hayball, Krasimir Vasilev

Research output: Contribution to journalArticlepeer-review

133 Citations (Scopus)


Infections arising from bacterial adhesion and colonization on medical device surfaces are a significant healthcare problem. Silver based antibacterial coatings have attracted a great deal of attention as a potential solution. This paper reports on the development of a silver nanoparticles based antibacterial surface that can be applied to any type of material surface. The silver nanoparticles were surface engineered with a monolayer of 2-mercaptosuccinic acid, which facilitates the immobilization of the nanoparticles to the solid surface, and also reduces the rate of oxidation of the nanoparticles, extending the lifetime of the coatings. The coatings had excellent antibacterial efficacy against three clinically significant pathogenic bacteria i.e. Staphylococcus epidermidis, Staphylococcus aureus and Pseudomonas aeruginosa. Studies with primary human fibroblast cells showed that the coatings had no cytotoxicity invitro. Innate immune studies in cultures of primary macrophages demonstrated that the coatings do not significantly alter the level of expression of pro-inflammatory cytokines or the adhesion and viability of these cells. Collectively, these coatings have an optimal combination of properties that make them attractive for deposition on medical device surfaces such as wound dressings, catheters and implants.

Original languageEnglish
Pages (from-to)4601-4609
Number of pages9
Issue number16
Publication statusPublished - May 2014
Externally publishedYes


  • Antibacterial surfaces
  • Cytotoxicity
  • Infections
  • Innate inflammatory response
  • Medical devices
  • Silver nanoparticles


Dive into the research topics of 'Substrate independent silver nanoparticle based antibacterial coatings'. Together they form a unique fingerprint.

Cite this