Success treatment of post-irradiation morphoea with acitretin and narrowband UVB

Kate Newland, Gillian Marshman

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)

    Abstract

    Post-irradiation morphoea is a rare but under-recognised complication of radiotherapy treatment for breast cancer. Management of this condition is difficult, and many cases are recalcitrant to therapy. A 43-year-old woman with breast cancer received radiotherapy following a mastectomy and partial axillary lymph node dissection, shortly after which she developed a hot, tender, erythematous and indurated plaque at the mastectomy site. Subsequently the skin became retracted, depressed and hyperpigmented. The clinical features, along with histological findings, were consistent with post-irradiation morphoea. Treatment with narrowband ultraviolet B and acitretin 10 mg daily was commenced 5 years following radiotherapy. After 2 months of therapy the patient reported significant improvement in tenderness and range of left arm movement. Objectively the plaque was less indurated and softer to palpation. We propose that this treatment regimen is an option in the management of post-irradiation morphoea.

    Original languageEnglish
    Pages (from-to)136-138
    Number of pages3
    JournalAustralasian Journal of Dermatology
    Volume53
    Issue number2
    DOIs
    Publication statusPublished - May 2012

    Keywords

    • post-irradiation morphoea
    • radiation-induced scleroderma

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