Suicide transport: Destruction of neurons by retrograde transport of Ricin, Abrin, and Modeccin

Ronald G. Wiley, W. W. Blessing, Donald J. Reis

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

Certain toxic lectins, including ricin, are retrogradely transported along neuronal processes to the cell body where they inactivate ribosomes, resulting in neuronal death. This process of "suicide transport" suggests a powerful new experimental strategy for solving neurobiological problems.

Original languageEnglish
Pages (from-to)889-890
Number of pages2
JournalScience
Volume216
Issue number4548
DOIs
Publication statusPublished - 21 May 1982
Externally publishedYes

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