Suppressing regrowth of microfluidic generated drug nanocrystals using polyelectrolyte coatings

Selvi Dev; Jeremiah Toster; S Prasanna; Melinda Fitzgerald; K Iyer; Colin Raston

doi:10.1039/c2ra22790h

Suppressing regrowth of microfluidic generated drug nanocrystals using polyelectrolyte coatings

Selvi Dev, Jeremiah Toster, S Prasanna, Melinda Fitzgerald, K Iyer, Colin Raston

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Crystalline meloxicam nanoparticles <100 nm in diameter are accessible using a microfluidic platform without the use of organic solvents, with a subsequent layer-by-layer polyelectrolyte encapsulation being effective in suppressing growth of macrocrystals, and imparting high colloidal stability for sustained release over 6-8 h with a t_1/2ca.180 min.

Original language	English
Pages (from-to)	695-698
Number of pages	4
Journal	RSC Advances
Volume	3
Issue number	3
DOIs	https://doi.org/10.1039/c2ra22790h
Publication status	Published - 21 Jan 2013

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abstract = "Crystalline meloxicam nanoparticles <100 nm in diameter are accessible using a microfluidic platform without the use of organic solvents, with a subsequent layer-by-layer polyelectrolyte encapsulation being effective in suppressing growth of macrocrystals, and imparting high colloidal stability for sustained release over 6-8 h with a t1/2ca.180 min.",

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AU - Toster, Jeremiah

AU - Prasanna, S

AU - Fitzgerald, Melinda

AU - Iyer, K

AU - Raston, Colin

PY - 2013/1/21

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Suppressing regrowth of microfluidic generated drug nanocrystals using polyelectrolyte coatings

Abstract

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