Supraesophageal Reflux Disease: Solving a Riddle Wrapped in a Mystery Inside an Enigma

Symptoms referable to irritation and inflammation of the pharynx, larynx, and bronchi are very common in the community. Hoarseness, persistent sore throat, globus, and chronic cough are present in up to 1 in 4 patients in the primary care setting and account for a large number of referrals to gastroenterologists, respiratory physicians and ear, nose, and throat (ENT) specialists.1 Epidemiologic research has documented an association between gastroesophageal reflux disease (GERD) and a range of “supraesophageal” symptoms and diseases...