Surface modification and chemical surface analysis of biomaterials

Peter Kingshott, Gunther Andersson, Sally McArthur, Hans Griesser

    Research output: Contribution to journalReview articlepeer-review

    67 Citations (Scopus)

    Abstract

    The chemical composition of the surface layers of synthetic biomaterials used for human medical devices and in biotechnology plays a key role in determining interfacial interactions between biological media (such as protein solutions, cells, tissue) and the synthetic material. Accordingly, considerable research efforts focus on improving the 'biocompatibility' of biomaterials by applying various surface modification and thin film coating approaches. Here we focus on the patterning of surface chemistries, often designed to exercise spatial control over events such as cell attachment and spreading. Secondly, we review recent developments in chemical characterisation of biomaterials surfaces, which is essential both for verifying the success of intended surface modification strategies and for reliable interpretation of observed biological responses. Biomaterials surface analysis by imaging ToF-SIMS and XPS and compositional depth profiling are discussed, as is the emerging complementary technique of Metastable Induced Electron Spectroscopy.

    Original languageEnglish
    Pages (from-to)667-676
    Number of pages10
    JournalCurrent Opinion in Chemical Biology
    Volume15
    Issue number5
    DOIs
    Publication statusPublished - Oct 2011

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