Surface profiles for subclassification of chronic lymphocytic leukemia: Leuk Lymphoma

Pauline Y. Huang, O. Giles Best, Larissa Belov, Stephen P. Mulligan, Rihcard I. Christopherson

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Chronic lymphocytic leukemia (CLL) has a variable clinical course. Some patients have stable disease while others progress and require treatment. Levels of several cluster of differentiation (CD) antigens are known to correlate with prognosis and may be used to stratify patients according to risk. In this review, we summarize current information on surface CD antigens found on CLL, their pathological significance and their detection using CD antibody microarrays. The use of extensive immunophenotypic patterns or surface profiles as disease signatures for CLL subclassification, prognosis and patient management is discussed with a focus on triaging patients with CLL with progressive disease.
Original languageEnglish
Pages (from-to)1046-1056
Number of pages11
JournalLeukemia & lymphoma
Issue number6
Publication statusPublished - 2012
Externally publishedYes


  • Antigens, CD/genetics/metabolism Antigens, Surface/*genetics/metabolism Biomarkers, Tumor/genetics/metabolism Disease Progression Gene Expression Profiling Humans Leukemia, Lymphocytic, Chronic, B-Cell/*classification/*diagnosis/genetics/pathology Microarray Analysis Models, Biological Neoplasm Staging/methods Prognosis


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