Surfactant replacement therapy in ARDS: White knight or noise in the system?

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    Abstract

    Although one would predict that surfactant replacement therapy would be effective in acute respiratory distress syndrome (ARDS), a recent large trial proved unsuccessful, possibly reflecting the nature of the surfactant used. Given the importance of the unique proteins in the action of surfactant, these would seem vital components of any exogenous surfactant. The ability to identify patients at risk of ARDS and to characterise their surfactant might allow prophylactic treatment with a nebulised, complementary, tailor-made preparation of surfactant. Advanced cases might undergo bronchoscopic focal lavage to remove plasma proteins and inflammatory mediators prior to focal instillation of surfactant to areas of greatest need. Ventilation regimens might be adjusted both to minimise trauma and to conserve endogenous surfactant.

    Original languageEnglish
    Pages (from-to)195-197
    Number of pages3
    JournalThorax
    Volume52
    Issue number2
    DOIs
    Publication statusPublished - 1 Jan 1997

    Keywords

    • ARDS
    • surfactant
    • surfactant associated proteins
    • surfactant replacement therapy

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