Surgical Antibiotic Prophylaxis in an Era of Antibiotic Resistance: Common Resistant Bacteria and Wider Considerations for Practice

Bradley D. Menz, Esmita Charani, David L. Gordon, Andrew J.M. Leather, S. Ramani Moonesinghe, Cameron J. Phillips

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)
1 Downloads (Pure)

Abstract

The increasing incidence of antimicrobial resistance (AMR) presents a global crisis to healthcare, with longstanding antimicrobial agents becoming less effective at treating and preventing infection. In the surgical setting, antibiotic prophylaxis has long been established as routine standard of care to prevent surgical site infection (SSI), which remains one of the most common hospital-acquired infections. The growing incidence of AMR increases the risk of SSI complicated with resistant bacteria, resulting in poorer surgical outcomes (prolonged hospitalisation, extended durations of antibiotic therapy, higher rates of surgical revision and mortality). Despite these increasing challenges, more data are required on approaches at the institutional and patient level to optimise surgical antibiotic prophylaxis in the era of antibiotic resistance (AR). This review provides an overview of the common resistant bacteria encountered in the surgical setting and covers wider considerations for practice to optimise surgical antibiotic prophylaxis in the perioperative setting.

Original languageEnglish
Pages (from-to)5235-5252
Number of pages18
JournalInfection and Drug Resistance
Volume14
DOIs
Publication statusPublished - 7 Dec 2021

Keywords

  • Antibiotic resistance
  • Antimicrobial stewardship
  • Perioperative care
  • Surgical antibiotic prophylaxis
  • Surgical site infection

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