Sustained Response to Deep Brain Stimulation in LRRK2 Parkinsonism with the Y1699C Mutation

L Perju-Dumbrava, M Mcdonald, Anthony Kneebone, R Long, Dominic Thyagarajan

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    Although effective deep brain stimulation of the subthalamic nucleus (STN-DBS) is reported in G2019S leucine-rich repeat kinase 2 (LRRK2) parkinsonism, response to surgery in other LRRK2 mutations has not been previously reported. We present an affected individual from the Lincolnshire pedigree (Y1699C), on whom bilateral STN-DBS was performed to control severe motor fluctuations and dyskinesias. He showed a marked improvement in Unified Parkinson's Disease Rating Scale (UPDRS) Part III scores in the 'on' and 'off' states, sustained for more than three years. Bilateral STN-DBS in LRRK2-parkinsonism with the Y1699C mutation can be as effective as in sporadic PD.

    Original languageEnglish
    Pages (from-to)269-271
    Number of pages3
    JournalJournal of Parkinson's Disease
    Volume2
    Issue number4
    DOIs
    Publication statusPublished - 2012

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