Aim of Symposium: Cardiovascular disease, cancer and diabetes are the leading causes of disease burden and mortality across western societies. All three diseases share common behavioural risk factors that include alcohol abuse, smoking, poor diet and low levels of physical activity. While there is strong support for the use of preventative approaches for these diseases, traditional treatment has tended to focus only on single risk behaviours. The aim of the symposium is to highlight the opportunities for clinicians to address multiple risk behaviours as part of their routine practice. The ﬁrst paper will highlight the clustering of multiple health risk behaviours in college populations. The second paper will highlight the prevalence of multiple risk behaviours in people from highly disadvantaged backgrounds. The third paper will present results from a systematic review of interventions addressing smoking, diet and physical activity amongst alcohol and other substance abuse populations. Nature of Interactive Element: Audience discussion will be encouraged.