Synovial tissue research: a state-of-the-art review

Carl Orr; Elsa Sousa; David L. Boyle; Maya H. Buch; Christopher D. Buckley; Juan D. Cañete; Anca I. Catrina; Ernest H.S. Choy; Paul Emery; Ursula Fearon; Andrew Filer; Danielle Gerlag; Frances Humby; John D. Isaacs; Søren A. Just; Bernard R. Lauwerys; Benoit Le Goff; Antonio Manzo; Trudy McGarry; Iain B. McInnes; Aurélie Najm; Constantino Pitzalis; Arthur Pratt; Malcolm Smith; Paul P. Tak; Sander Tas; Rogier Thurlings; João E. Fonseca; Douglas J. Veale

doi:10.1038/nrrheum.2017.115

Synovial tissue research: a state-of-the-art review

Carl Orr, Elsa Sousa, David L. Boyle, Maya H. Buch, Christopher D. Buckley, Juan D. Cañete, Anca I. Catrina, Ernest H.S. Choy, Paul Emery, Ursula Fearon, Andrew Filer, Danielle Gerlag, Frances Humby, John D. Isaacs, Søren A. Just, Bernard R. Lauwerys, Benoit Le Goff, Antonio Manzo, Trudy McGarry, Iain B. McInnesAurélie Najm, Constantino Pitzalis, Arthur Pratt, Malcolm Smith, Paul P. Tak, Sander Tas, Rogier Thurlings, João E. Fonseca, Douglas J. Veale

Research output: Contribution to journal › Review article › peer-review

181 Citations (Scopus)

Abstract

The synovium is the major target tissue of inflammatory arthritides such as rheumatoid arthritis. The study of synovial tissue has advanced considerably throughout the past few decades from arthroplasty and blind needle biopsy to the use of arthroscopic and ultrasonographic technologies that enable easier visualization and improve the reliability of synovial biopsies. Rapid progress has been made in using synovial tissue to study disease pathogenesis, to stratify patients, to discover biomarkers and novel targets, and to validate therapies, and this progress has been facilitated by increasingly diverse and sophisticated analytical and technological approaches. In this Review, we describe these approaches, and summarize how their use in synovial tissue research has improved our understanding of rheumatoid arthritis and identified candidate biomarkers that could be used in disease diagnosis and stratification, as well as in predicting disease course and treatment response.

Original language	English
Pages (from-to)	463-475
Number of pages	13
Journal	Nature Reviews Rheumatology
Volume	13
Issue number	8
DOIs	https://doi.org/10.1038/nrrheum.2017.115
Publication status	Published - Aug 2017

Keywords

diagnostic markers
Rheumatoid arthritis
synovial tissue
arthritides
disease pathogenesis

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Orr, C., Sousa, E., Boyle, D. L., Buch, M. H., Buckley, C. D., Cañete, J. D., Catrina, A. I., Choy, E. H. S., Emery, P., Fearon, U., Filer, A., Gerlag, D., Humby, F., Isaacs, J. D., Just, S. A., Lauwerys, B. R., Le Goff, B., Manzo, A., McGarry, T., ... Veale, D. J. (2017). Synovial tissue research: a state-of-the-art review. Nature Reviews Rheumatology, 13(8), 463-475. https://doi.org/10.1038/nrrheum.2017.115

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title = "Synovial tissue research: a state-of-the-art review",

abstract = "The synovium is the major target tissue of inflammatory arthritides such as rheumatoid arthritis. The study of synovial tissue has advanced considerably throughout the past few decades from arthroplasty and blind needle biopsy to the use of arthroscopic and ultrasonographic technologies that enable easier visualization and improve the reliability of synovial biopsies. Rapid progress has been made in using synovial tissue to study disease pathogenesis, to stratify patients, to discover biomarkers and novel targets, and to validate therapies, and this progress has been facilitated by increasingly diverse and sophisticated analytical and technological approaches. In this Review, we describe these approaches, and summarize how their use in synovial tissue research has improved our understanding of rheumatoid arthritis and identified candidate biomarkers that could be used in disease diagnosis and stratification, as well as in predicting disease course and treatment response.",

keywords = "diagnostic markers, Rheumatoid arthritis, synovial tissue, arthritides, disease pathogenesis",

author = "Carl Orr and Elsa Sousa and Boyle, {David L.} and Buch, {Maya H.} and Buckley, {Christopher D.} and Ca{\~n}ete, {Juan D.} and Catrina, {Anca I.} and Choy, {Ernest H.S.} and Paul Emery and Ursula Fearon and Andrew Filer and Danielle Gerlag and Frances Humby and Isaacs, {John D.} and Just, {S{\o}ren A.} and Lauwerys, {Bernard R.} and {Le Goff}, Benoit and Antonio Manzo and Trudy McGarry and McInnes, {Iain B.} and Aur{\'e}lie Najm and Constantino Pitzalis and Arthur Pratt and Malcolm Smith and Tak, {Paul P.} and Sander Tas and Rogier Thurlings and Fonseca, {Jo{\~a}o E.} and Veale, {Douglas J.}",

year = "2017",

month = aug,

doi = "10.1038/nrrheum.2017.115",

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Orr, C, Sousa, E, Boyle, DL, Buch, MH, Buckley, CD, Cañete, JD, Catrina, AI, Choy, EHS, Emery, P, Fearon, U, Filer, A, Gerlag, D, Humby, F, Isaacs, JD, Just, SA, Lauwerys, BR, Le Goff, B, Manzo, A, McGarry, T, McInnes, IB, Najm, A, Pitzalis, C, Pratt, A, Smith, M, Tak, PP, Tas, S, Thurlings, R, Fonseca, JE & Veale, DJ 2017, 'Synovial tissue research: a state-of-the-art review', Nature Reviews Rheumatology, vol. 13, no. 8, pp. 463-475. https://doi.org/10.1038/nrrheum.2017.115

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AU - Pitzalis, Constantino

AU - Pratt, Arthur

AU - Smith, Malcolm

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AU - Veale, Douglas J.

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AB - The synovium is the major target tissue of inflammatory arthritides such as rheumatoid arthritis. The study of synovial tissue has advanced considerably throughout the past few decades from arthroplasty and blind needle biopsy to the use of arthroscopic and ultrasonographic technologies that enable easier visualization and improve the reliability of synovial biopsies. Rapid progress has been made in using synovial tissue to study disease pathogenesis, to stratify patients, to discover biomarkers and novel targets, and to validate therapies, and this progress has been facilitated by increasingly diverse and sophisticated analytical and technological approaches. In this Review, we describe these approaches, and summarize how their use in synovial tissue research has improved our understanding of rheumatoid arthritis and identified candidate biomarkers that could be used in disease diagnosis and stratification, as well as in predicting disease course and treatment response.

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Synovial tissue research: a state-of-the-art review

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Keywords

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