TY - JOUR
T1 - Synovial tissue research
T2 - A state-of-the-art review
AU - Orr, Carl
AU - Sousa, Elsa
AU - Boyle, David L.
AU - Buch, Maya H.
AU - Buckley, Christopher D.
AU - Cañete, Juan D.
AU - Catrina, Anca I.
AU - Choy, Ernest H.S.
AU - Emery, Paul
AU - Fearon, Ursula
AU - Filer, Andrew
AU - Gerlag, Danielle
AU - Humby, Frances
AU - Isaacs, John D.
AU - Just, Søren A.
AU - Lauwerys, Bernard R.
AU - Le Goff, Benoit
AU - Manzo, Antonio
AU - McGarry, Trudy
AU - McInnes, Iain B.
AU - Najm, Aurélie
AU - Pitzalis, Constantino
AU - Pratt, Arthur
AU - Smith, Malcolm
AU - Tak, Paul P.
AU - Tas, Sander
AU - Thurlings, Rogier
AU - Fonseca, João E.
AU - Veale, Douglas J.
PY - 2017/8
Y1 - 2017/8
N2 - The synovium is the major target tissue of inflammatory arthritides such as rheumatoid arthritis. The study of synovial tissue has advanced considerably throughout the past few decades from arthroplasty and blind needle biopsy to the use of arthroscopic and ultrasonographic technologies that enable easier visualization and improve the reliability of synovial biopsies. Rapid progress has been made in using synovial tissue to study disease pathogenesis, to stratify patients, to discover biomarkers and novel targets, and to validate therapies, and this progress has been facilitated by increasingly diverse and sophisticated analytical and technological approaches. In this Review, we describe these approaches, and summarize how their use in synovial tissue research has improved our understanding of rheumatoid arthritis and identified candidate biomarkers that could be used in disease diagnosis and stratification, as well as in predicting disease course and treatment response.
AB - The synovium is the major target tissue of inflammatory arthritides such as rheumatoid arthritis. The study of synovial tissue has advanced considerably throughout the past few decades from arthroplasty and blind needle biopsy to the use of arthroscopic and ultrasonographic technologies that enable easier visualization and improve the reliability of synovial biopsies. Rapid progress has been made in using synovial tissue to study disease pathogenesis, to stratify patients, to discover biomarkers and novel targets, and to validate therapies, and this progress has been facilitated by increasingly diverse and sophisticated analytical and technological approaches. In this Review, we describe these approaches, and summarize how their use in synovial tissue research has improved our understanding of rheumatoid arthritis and identified candidate biomarkers that could be used in disease diagnosis and stratification, as well as in predicting disease course and treatment response.
KW - diagnostic markers
KW - Rheumatoid arthritis
KW - synovial tissue
KW - arthritides
KW - disease pathogenesis
UR - http://www.scopus.com/inward/record.url?scp=85026647952&partnerID=8YFLogxK
U2 - 10.1038/nrrheum.2017.115
DO - 10.1038/nrrheum.2017.115
M3 - Review article
C2 - 28701760
AN - SCOPUS:85026647952
VL - 13
SP - 463
EP - 475
JO - Nature Reviews Rheumatology
JF - Nature Reviews Rheumatology
SN - 1759-4790
IS - 8
ER -