Synthesis and characterization of chitosan/dextran-based hydrogels for surgical use

G. Liu; Z. Shi; T. Kuriger; L. R. Hanton; J. Simpson; S. C. Moratti; B. H. Robinson; T. Athanasiadis; R. Valentine; P. J. Wormald; S. Robinson

doi:10.1002/masy.200950523

Synthesis and characterization of chitosan/dextran-based hydrogels for surgical use

G. Liu, Z. Shi, T. Kuriger, L. R. Hanton, J. Simpson, S. C. Moratti, B. H. Robinson, T. Athanasiadis, R. Valentine, P. J. Wormald, S. Robinson

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

A series of hydrogels were formed from the reaction between an amine functionalized succinyl chitosan and an oxidized dextran. The properties and rate of formation of the gel were related to both the amine and aldehyde levels of the precursors. These levels could be readily changed by altering the reaction conditions, and allowed good control of the gel properties. Oxidation of the dextran with periodate was accompanied by chain scission and a large reduction in molecular weight. The gel showed excellent haemostatic properties and reduction of adhesions in animal models.

Original language	English
Pages (from-to)	151-157
Number of pages	7
Journal	Macromolecular Symposia
Volume	279
Issue number	1
DOIs	https://doi.org/10.1002/masy.200950523
Publication status	Published - May 2009
Externally published	Yes

Keywords

Adhesions
Chitosan
Dextran
Hydrogel
Imine
Oxidized periodate
Succinylation

Access to Document

10.1002/masy.200950523Licence: In Copyright

Cite this

@article{85d9e579d06f41c5b41560332f33d6ea,

title = "Synthesis and characterization of chitosan/dextran-based hydrogels for surgical use",

abstract = "A series of hydrogels were formed from the reaction between an amine functionalized succinyl chitosan and an oxidized dextran. The properties and rate of formation of the gel were related to both the amine and aldehyde levels of the precursors. These levels could be readily changed by altering the reaction conditions, and allowed good control of the gel properties. Oxidation of the dextran with periodate was accompanied by chain scission and a large reduction in molecular weight. The gel showed excellent haemostatic properties and reduction of adhesions in animal models.",

keywords = "Adhesions, Chitosan, Dextran, Hydrogel, Imine, Oxidized periodate, Succinylation",

author = "G. Liu and Z. Shi and T. Kuriger and Hanton, {L. R.} and J. Simpson and Moratti, {S. C.} and Robinson, {B. H.} and T. Athanasiadis and R. Valentine and Wormald, {P. J.} and S. Robinson",

year = "2009",

month = may,

doi = "10.1002/masy.200950523",

language = "English",

volume = "279",

pages = "151--157",

journal = "Macromolecular Symposia",

issn = "1022-1360",

publisher = "Wiley",

number = "1",

}

TY - JOUR

T1 - Synthesis and characterization of chitosan/dextran-based hydrogels for surgical use

AU - Liu, G.

AU - Shi, Z.

AU - Kuriger, T.

AU - Hanton, L. R.

AU - Simpson, J.

AU - Moratti, S. C.

AU - Robinson, B. H.

AU - Athanasiadis, T.

AU - Valentine, R.

AU - Wormald, P. J.

AU - Robinson, S.

PY - 2009/5

Y1 - 2009/5

N2 - A series of hydrogels were formed from the reaction between an amine functionalized succinyl chitosan and an oxidized dextran. The properties and rate of formation of the gel were related to both the amine and aldehyde levels of the precursors. These levels could be readily changed by altering the reaction conditions, and allowed good control of the gel properties. Oxidation of the dextran with periodate was accompanied by chain scission and a large reduction in molecular weight. The gel showed excellent haemostatic properties and reduction of adhesions in animal models.

AB - A series of hydrogels were formed from the reaction between an amine functionalized succinyl chitosan and an oxidized dextran. The properties and rate of formation of the gel were related to both the amine and aldehyde levels of the precursors. These levels could be readily changed by altering the reaction conditions, and allowed good control of the gel properties. Oxidation of the dextran with periodate was accompanied by chain scission and a large reduction in molecular weight. The gel showed excellent haemostatic properties and reduction of adhesions in animal models.

KW - Adhesions

KW - Chitosan

KW - Dextran

KW - Hydrogel

KW - Imine

KW - Oxidized periodate

KW - Succinylation

UR - http://www.scopus.com/inward/record.url?scp=67649980479&partnerID=8YFLogxK

U2 - 10.1002/masy.200950523

DO - 10.1002/masy.200950523

M3 - Article

AN - SCOPUS:67649980479

SN - 1022-1360

VL - 279

SP - 151

EP - 157

JO - Macromolecular Symposia

JF - Macromolecular Symposia

IS - 1

ER -

Synthesis and characterization of chitosan/dextran-based hydrogels for surgical use

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this