Synthesis and Characterization of Novel Anchorlipids for Tethered Bilayer Lipid Membranes

Jakob Andersson, Jacqueline Knobloch, Michael Perkins, Stephen Holt, Ingo Koper

    Research output: Contribution to journalArticlepeer-review

    18 Citations (Scopus)


    Tethered bilayer lipid membranes are versatile solid-supported model membrane systems. Core to these systems is an anchorlipid that covalently links a lipid bilayer to a support. The molecular structure of these lipids can have a significant impact on the properties of the resulting bilayer. Here, the synthesis of anchorlipids containing ester groups in the tethering part is described. The lipids are used to form bilayer membranes, and the resulting structures are compared with membranes formed using conventional anchorlipids or sparsely tethered membranes. All membranes showed good electrical sealing properties; the disulphide-terminated anchorlipids could be used in a sparsely tethered system without significantly reducing the sealing properties of the lipid bilayers. The sparsely tethered systems also allowed for higher ion transport across the membrane, which is in good correlation with higher hydration of the spacer region as seen by neutron scattering.

    Original languageEnglish
    Pages (from-to)4444-4451
    Number of pages8
    Issue number18
    Early online date2017
    Publication statusPublished - 9 May 2017


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