Synthesis of Cationic Silver Nanoparticles with Highly Potent Properties against Oral Pathogens and Their Biofilms

Yanping He, Don Hashan Kevin Ketagoda, Richard Bright, Susan Marie Britza, Joshua Zechner, Ian Musgrave, Krasimir Vasilev, Peter Zilm

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)
22 Downloads (Pure)

Abstract

Dental caries is a major disease associated with the proliferation of acidogenic bacterial species such as Streptococcus mutans that are part of the commensal microbiota of the mouth. Silver nanoparticles (AgNPs) are attractive antibacterial agents as they target multiple sites in bacteria which reduces antimicrobial resistance. In this study, we synthesised stable, highly positively charged AgNPs capped with branched PEI (BPEI-AgNPs) and characterized them using UV–vis absorption, transmission electron microscopy (TEM), the size of which were approximately 7.5 nm. The antibacterial activity and anti-biofilm capacity of BPEI-AgNPs was investigated against cariogenic bacteria. Our results demonstrated that BPEI-AgNPs are potent clinical oral antiseptics. The cytotoxicity of the BPEI-AgNPs was also studied against two mammalian cell lines. The results indicated that BPEI-AgNPs were non-cytotoxic and were safer than commercially used dental antiseptics. We conclude that the BPEI-AgNPs are safe for oral clinical application and are an effective oral antimicrobial agent.

Original languageEnglish
Article numbere202200472
Number of pages9
JournalChemNanoMat
Volume9
Issue number3
Early online date12 Jan 2023
DOIs
Publication statusPublished - Mar 2023

Keywords

  • Antibiofilm
  • Branch polyethylenimine
  • Chlorhexidine. Dental caries
  • Silver nanoparticle

Fingerprint

Dive into the research topics of 'Synthesis of Cationic Silver Nanoparticles with Highly Potent Properties against Oral Pathogens and Their Biofilms'. Together they form a unique fingerprint.

Cite this