Synthesis of myo-inositol 1,2,4,5-tetrakisphosphate, a Ca2+-mobilising tetrakisphosphate with a potency similar to myo-inositol 1,4,5-trisphosphate

Stephen J. Mills; Stephen T. Safrany; Robert A. Wilcox; Stefan R. Nahorski; Barry VL Potter

doi:10.1016/S0960-894X(00)80007-4

Synthesis of myo-inositol 1,2,4,5-tetrakisphosphate, a Ca²⁺-mobilising tetrakisphosphate with a potency similar to myo-inositol 1,4,5-trisphosphate

Stephen J. Mills, Stephen T. Safrany, Robert A. Wilcox, Stefan R. Nahorski, Barry VL Potter

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23 Citations (Scopus)

Abstract

The synthesis of myo-inositol 1,2,4,5-tetrakisphosphate from inositol is described; this tetrakisphosphate is a highly potent Ca²⁺-mobilising agonist at the Ins(1,4,5)P₃ receptor.

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@article{f155221137ab45dcb8f9bdf9e6bea7e0,

title = "Synthesis of myo-inositol 1,2,4,5-tetrakisphosphate, a Ca2+-mobilising tetrakisphosphate with a potency similar to myo-inositol 1,4,5-trisphosphate",

abstract = "The synthesis of myo-inositol 1,2,4,5-tetrakisphosphate from inositol is described; this tetrakisphosphate is a highly potent Ca2+-mobilising agonist at the Ins(1,4,5)P3 receptor.",

author = "Mills, {Stephen J.} and Safrany, {Stephen T.} and Wilcox, {Robert A.} and Nahorski, {Stefan R.} and Potter, {Barry VL}",

year = "1993",

month = aug,

doi = "10.1016/S0960-894X(00)80007-4",

language = "English",

volume = "3",

pages = "1505--1510",

journal = "Bioorganic & Medicinal Chemistry Letters",

issn = "0960-894X",

number = "8",

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T1 - Synthesis of myo-inositol 1,2,4,5-tetrakisphosphate, a Ca2+-mobilising tetrakisphosphate with a potency similar to myo-inositol 1,4,5-trisphosphate

AU - Mills, Stephen J.

AU - Safrany, Stephen T.

AU - Wilcox, Robert A.

AU - Nahorski, Stefan R.

AU - Potter, Barry VL

PY - 1993/8

Y1 - 1993/8

N2 - The synthesis of myo-inositol 1,2,4,5-tetrakisphosphate from inositol is described; this tetrakisphosphate is a highly potent Ca2+-mobilising agonist at the Ins(1,4,5)P3 receptor.

AB - The synthesis of myo-inositol 1,2,4,5-tetrakisphosphate from inositol is described; this tetrakisphosphate is a highly potent Ca2+-mobilising agonist at the Ins(1,4,5)P3 receptor.

UR - http://www.scopus.com/inward/record.url?scp=0027203819&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(00)80007-4

DO - 10.1016/S0960-894X(00)80007-4

M3 - Article

AN - SCOPUS:0027203819

SN - 0960-894X

VL - 3

SP - 1505

EP - 1510

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 8

ER -

Synthesis of myo-inositol 1,2,4,5-tetrakisphosphate, a Ca²⁺-mobilising tetrakisphosphate with a potency similar to myo-inositol 1,4,5-trisphosphate

Abstract

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