Synthesis of novel metabolically stable analogues of D-myo-inositol 1,4,5-trisphosphate

Abdul H. Fauq; Javid H. Zaidi; Robert A. Wilcox; Girlie Varvel; Stefan R. Nahorski; Alan P. Kozikowski; Christophé Erneux

doi:10.1016/0040-4039(96)00169-4

Synthesis of novel metabolically stable analogues of D-myo-inositol 1,4,5-trisphosphate

Abdul H. Fauq, Javid H. Zaidi, Robert A. Wilcox, Girlie Varvel, Stefan R. Nahorski, Alan P. Kozikowski, Christophé Erneux

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Starting from L-quebrachitol, syntheses and biological activities of three novel analogues of the cellular second messenger D-myo-inositol 1,4,5-trisphosphate (IP₃), 3-deoxy-3-fluoro-D-myo-inositol 1,4-bisphosphate 5-phosphorothioate (1a), 3-deoxy-3-fluoro-D-myo-inositol 1,5-bisphosphate 4-phosphorothioate (1b), and 3-deoxy-3-fluoro-D-myo-inositol 1-phosphate 4,5-bisphosphorothioate (1c) are described.

Original language	English
Pages (from-to)	1917-1920
Number of pages	4
Journal	Tetrahedron Letters
Volume	37
Issue number	12
DOIs	https://doi.org/10.1016/0040-4039(96)00169-4
Publication status	Published - 18 Mar 1996
Externally published	Yes

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@article{c12198270fbf4588a8aabd5005f017e0,

title = "Synthesis of novel metabolically stable analogues of D-myo-inositol 1,4,5-trisphosphate",

abstract = "Starting from L-quebrachitol, syntheses and biological activities of three novel analogues of the cellular second messenger D-myo-inositol 1,4,5-trisphosphate (IP3), 3-deoxy-3-fluoro-D-myo-inositol 1,4-bisphosphate 5-phosphorothioate (1a), 3-deoxy-3-fluoro-D-myo-inositol 1,5-bisphosphate 4-phosphorothioate (1b), and 3-deoxy-3-fluoro-D-myo-inositol 1-phosphate 4,5-bisphosphorothioate (1c) are described.",

author = "Fauq, {Abdul H.} and Zaidi, {Javid H.} and Wilcox, {Robert A.} and Girlie Varvel and Nahorski, {Stefan R.} and Kozikowski, {Alan P.} and Christoph{\'e} Erneux",

year = "1996",

month = mar,

day = "18",

doi = "10.1016/0040-4039(96)00169-4",

language = "English",

volume = "37",

pages = "1917--1920",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Pergamon-Elseveir Science Ltd",

number = "12",

}

TY - JOUR

T1 - Synthesis of novel metabolically stable analogues of D-myo-inositol 1,4,5-trisphosphate

AU - Fauq, Abdul H.

AU - Zaidi, Javid H.

AU - Wilcox, Robert A.

AU - Varvel, Girlie

AU - Nahorski, Stefan R.

AU - Kozikowski, Alan P.

AU - Erneux, Christophé

PY - 1996/3/18

Y1 - 1996/3/18

N2 - Starting from L-quebrachitol, syntheses and biological activities of three novel analogues of the cellular second messenger D-myo-inositol 1,4,5-trisphosphate (IP3), 3-deoxy-3-fluoro-D-myo-inositol 1,4-bisphosphate 5-phosphorothioate (1a), 3-deoxy-3-fluoro-D-myo-inositol 1,5-bisphosphate 4-phosphorothioate (1b), and 3-deoxy-3-fluoro-D-myo-inositol 1-phosphate 4,5-bisphosphorothioate (1c) are described.

AB - Starting from L-quebrachitol, syntheses and biological activities of three novel analogues of the cellular second messenger D-myo-inositol 1,4,5-trisphosphate (IP3), 3-deoxy-3-fluoro-D-myo-inositol 1,4-bisphosphate 5-phosphorothioate (1a), 3-deoxy-3-fluoro-D-myo-inositol 1,5-bisphosphate 4-phosphorothioate (1b), and 3-deoxy-3-fluoro-D-myo-inositol 1-phosphate 4,5-bisphosphorothioate (1c) are described.

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U2 - 10.1016/0040-4039(96)00169-4

DO - 10.1016/0040-4039(96)00169-4

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JF - Tetrahedron Letters

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