Synthetic strategies for radioligands for in vivo imaging of brain cannabinoid type-1 receptors

Muneer Ahamed, Alfons Verbruggen, Guy Bormans

    Research output: Contribution to journalReview articlepeer-review

    1 Citation (Scopus)

    Abstract

    Despite its abundant expression in the brain, the cannabinoid type-1 (CB1) receptor was discovered only in 1988. During the last decade, efforts from several research groups have made it possible to visualize the CB1 receptor in vivo to unravel its role in the brain physiology and pathology. This review discusses strategies for (radio)synthesis of radioligands for in vivo imaging of CB1 receptors.

    Original languageEnglish
    Pages (from-to)207-214
    Number of pages8
    JournalJournal of Labelled Compounds and Radiopharmaceuticals
    Volume56
    Issue number3-4
    DOIs
    Publication statusPublished - Mar 2013

    Keywords

    • CB1 receptors
    • in vivo imaging
    • positron emission tomography
    • radiosynthesis

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