Systemic concentrations of asymmetric dimethylarginine (ADMA) in chronic obstructive pulmonary disease (COPD): state of the art

Angelo Zinellu, Alessandro G. Fois, Arduino A. Mangoni, Panagiotis Paliogiannis, Elisabetta Sotgiu, Elisabetta Zinellu, Viviana Marras, Pietro Pirina, Ciriaco Carru

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Experimental evidence suggests that oxidative stress (OS) may increase the activity of arginine methylating enzymes that produce the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA). In addition, it is well documented that OS can significantly decrease the synthesis and/or activity of ADMA degrading enzymes, thus causing ADMA accumulation in biological fluids. Recent reports have focused on circulating methylated arginine concentrations in chronic obstructive pulmonary disease, a disease characterized by a significant increase in OS. This review discusses the results of these studies and the opportunities for further research in this area.

Original languageEnglish
Pages (from-to)1169-1176
Number of pages8
JournalAMINO ACIDS
Volume50
Issue number9
DOIs
Publication statusPublished - 1 Sep 2018

Keywords

  • ADMA
  • Arginine
  • Chronic obstructive pulmonary disease
  • Inflammation
  • Oxidative stress

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