T-lymphocyte involvement in abscess formation in nonimmune mice

M. F. Nulsen, J. J. Finlay-Jones, P. J. McDonald

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)


    Athymic mice formed significantly smaller abscesses than euthymic mice in response to the intraperitoneal inoculation of an abscess-inducing mixture of Escherichia coli, Bacteroides fragilis, and autoclaved colonic contents, an abscess-potentiating agent. Adoptive transfer of nonimmune, Thy-1-positive spleen cells to athymic mice restored their ability to make abscesses of sizes similar to those in controls, indicating that T lymphocytes contribute to abscess formation in normal mice.

    Original languageEnglish
    Pages (from-to)633-636
    Number of pages4
    JournalInfection and Immunity
    Issue number2
    Publication statusPublished - May 1986


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