Targeting arachidonic acid pathway-associated NF-κB in pancreatic cancer

Nagendra Sastry Yarla, Olga Sukocheva, Ilaria Peluso, Swathi Putta, Pallaval Veera Bramhachari, Rajesh Yadala, Dinesh K. Tiwari, Srinivas Jagarlamudi, Luciana Scotti, Marcus T. Scotti, Marcella Reale, Mohammad Amjad Kamal, Ashraf Ghulam, Bechan Sharma, Madhukiran Parvathaneni, Chinthalapally V. Rao, Mastan Mannarapu, Anupam Bishayee

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Pancreatic cancer is one of the foremost causes of cancer-related death in the United States and worldwide. Nuclear factor-kappa B (NF-κB) is a transcription factor which plays a pivotal involvement in pancreatic cancer owing to its connection at the downstream stage of many signaling cascades including arachidonic acid (AA) pathway. AA cascade is an upstream pathway and regulator of NF-κB pathway. Moreover, NF-κB can bind to the cis-acting elements in the promoter of phospholipase A2s, cyclooxygenases, and lipoxygenases, and these pathways are upregulated in a variety of cancers. Several investigators have proved that AA pathway-associated NF-κB has key role in pathophysiology of pancreatic cancer and has been considered as a vital therapeutic target. Several phytochemicals have been explored as novel therapeutic and preventive agents by targeting AA cascade-associated NF-κB pathway. In this chapter, the role of AA cascade-associated NF-κB pathway in pancreatic cancer has been reviewed and discussed about plant-derived inhibitors of this pathway for the prevention and the therapy of pancreatic cancer.

Original languageEnglish
Title of host publicationRole of Transcription Factors in Gastrointestinal Malignancies
EditorsGanji Purnachandra Nagaraju, Pallaval Veera Bramhachari
Place of PublicationSingapore
PublisherSpringer Singapore
Pages403-411
Number of pages9
ISBN (Electronic)9789811067280
ISBN (Print)9789811067273
DOIs
Publication statusPublished - 3 Apr 2018

Keywords

  • Arachidonic acid pathway
  • Natural products
  • NF-κB
  • Pancreatic cancer

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