Targeting psychological and menopausal factors linked to non-adherence to anti-estrogen therapy in women with early-stage hormone-receptor positive breast cancer: A web-based feasibility study of Finding My Way

Margo Nathan; Lisa Beatty; Jamie Coborn; Aleta Wiley; Akanksha Srivastava; Julia Russell; Hadine Joffe

doi:10.1002/pon.6195

Targeting psychological and menopausal factors linked to non-adherence to anti-estrogen therapy in women with early-stage hormone-receptor positive breast cancer: A web-based feasibility study of Finding My Way

Margo Nathan, Lisa Beatty, Jamie Coborn, Aleta Wiley, Akanksha Srivastava, Julia Russell, Hadine Joffe

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Key Points
Reduced adherence to anti-estrogen therapy (AET; tamoxifen and aromatase inhibitors) in women with early-stage hormone-receptor-positive (HR+) breast cancers leads to adverse clinical outcomes.

Modifiable psychological factors (e.g., depressive symptoms and anxiety) and menopausal symptoms (e.g., sleep disturbance and hot flashes) are linked with diminished adherence.

An intervention targeting psychological and menopausal symptoms has potential to improve AET adherence.

We conducted a pilot study to evaluate the feasibility of a remotely administered behavioral intervention in women with early-stage HR+ breast cancer taking AET at-risk for non-adherence with psychological and menopausal symptoms.

Findings from this preliminary study show that a web-based behavioral intervention is feasible and may be a potential method of reducing risk for AET non-adherence in some patients.

Original language	English
Pages (from-to)	1461-1465
Number of pages	5
Journal	Psycho-Oncology
Volume	32
Issue number	9
Early online date	26 Jul 2023
DOIs	https://doi.org/10.1002/pon.6195
Publication status	Published - Sept 2023

Keywords

adherence
anxiety
breast cancer
cancer
depression
insomnia
intervention
menopause
oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Nathan, M., Beatty, L., Coborn, J., Wiley, A., Srivastava, A., Russell, J., & Joffe, H. (2023). Targeting psychological and menopausal factors linked to non-adherence to anti-estrogen therapy in women with early-stage hormone-receptor positive breast cancer: A web-based feasibility study of Finding My Way. Psycho-Oncology, 32(9), 1461-1465. https://doi.org/10.1002/pon.6195

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abstract = "Key PointsReduced adherence to anti-estrogen therapy (AET; tamoxifen and aromatase inhibitors) in women with early-stage hormone-receptor-positive (HR+) breast cancers leads to adverse clinical outcomes.Modifiable psychological factors (e.g., depressive symptoms and anxiety) and menopausal symptoms (e.g., sleep disturbance and hot flashes) are linked with diminished adherence.An intervention targeting psychological and menopausal symptoms has potential to improve AET adherence.We conducted a pilot study to evaluate the feasibility of a remotely administered behavioral intervention in women with early-stage HR+ breast cancer taking AET at-risk for non-adherence with psychological and menopausal symptoms.Findings from this preliminary study show that a web-based behavioral intervention is feasible and may be a potential method of reducing risk for AET non-adherence in some patients.",

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Nathan, M, Beatty, L, Coborn, J, Wiley, A, Srivastava, A, Russell, J & Joffe, H 2023, 'Targeting psychological and menopausal factors linked to non-adherence to anti-estrogen therapy in women with early-stage hormone-receptor positive breast cancer: A web-based feasibility study of Finding My Way', Psycho-Oncology, vol. 32, no. 9, pp. 1461-1465. https://doi.org/10.1002/pon.6195

Targeting psychological and menopausal factors linked to non-adherence to anti-estrogen therapy in women with early-stage hormone-receptor positive breast cancer: A web-based feasibility study of Finding My Way. / Nathan, Margo; Beatty, Lisa; Coborn, Jamie et al.
In: Psycho-Oncology, Vol. 32, No. 9, 09.2023, p. 1461-1465.

Research output: Contribution to journal › Article › peer-review

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