TY - JOUR
T1 - Telephone-based weight loss support for patients with knee osteoarthritis
T2 - a pragmatic randomised controlled trial
AU - O'Brien, K. M.
AU - Wiggers, J.
AU - Williams, A.
AU - Campbell, E.
AU - Hodder, R. K.
AU - Wolfenden, L.
AU - Yoong, S. L.
AU - Robson, E. K.
AU - Haskins, R.
AU - Kamper, S. J.
AU - Rissel, C.
AU - Williams, C. M.
PY - 2018/4
Y1 - 2018/4
N2 - Objective: To determine the effectiveness of telephone-based weight loss support in reducing the intensity of knee pain in patients with knee osteoarthritis, who are overweight or obese, compared to usual care. Design: We conducted a parallel randomised controlled trial (RCT), embedded within a cohort multiple RCT of patients on a waiting list for outpatient orthopaedic consultation at a tertiary referral hospital in NSW, Australia. Patients with knee osteoarthritis, classified as overweight or obese [body mass index (BMI) between ≥27 kg/m2 and <40 kg/m2] were randomly allocated to receive referral to an existing non-disease specific government funded 6-month telephone-based weight management and healthy lifestyle service or usual care. The primary outcome was knee pain intensity measured using an 11-point numerical rating scale (NRS) over 6-month follow-up. A number of secondary outcomes, including self-reported weight were measured. Data analysis was by intention-to-treat according to a pre-published analysis plan. Results: Between May 19 and June 30 2015, 120 patients were randomly assigned to the intervention (59 analysed, one post-randomisation exclusion) or usual care (60 analysed). We found no statistically significant between group differences in pain intensity [area under the curve (AUC), mean difference 5.4, 95%CI: −13.7 to 24.5, P = 0.58] or weight change at 6 months (self-reported; mean difference −0.4, 95%CI: −2.6 to 1.8, P = 0.74). Conclusions: Among patients with knee osteoarthritis who are overweight, telephone-based weight loss support, provided using an existing 6-month weight management and healthy lifestyle service did not reduce knee pain intensity or weight, compared with usual care. Trial registration number: ACTRN12615000490572
AB - Objective: To determine the effectiveness of telephone-based weight loss support in reducing the intensity of knee pain in patients with knee osteoarthritis, who are overweight or obese, compared to usual care. Design: We conducted a parallel randomised controlled trial (RCT), embedded within a cohort multiple RCT of patients on a waiting list for outpatient orthopaedic consultation at a tertiary referral hospital in NSW, Australia. Patients with knee osteoarthritis, classified as overweight or obese [body mass index (BMI) between ≥27 kg/m2 and <40 kg/m2] were randomly allocated to receive referral to an existing non-disease specific government funded 6-month telephone-based weight management and healthy lifestyle service or usual care. The primary outcome was knee pain intensity measured using an 11-point numerical rating scale (NRS) over 6-month follow-up. A number of secondary outcomes, including self-reported weight were measured. Data analysis was by intention-to-treat according to a pre-published analysis plan. Results: Between May 19 and June 30 2015, 120 patients were randomly assigned to the intervention (59 analysed, one post-randomisation exclusion) or usual care (60 analysed). We found no statistically significant between group differences in pain intensity [area under the curve (AUC), mean difference 5.4, 95%CI: −13.7 to 24.5, P = 0.58] or weight change at 6 months (self-reported; mean difference −0.4, 95%CI: −2.6 to 1.8, P = 0.74). Conclusions: Among patients with knee osteoarthritis who are overweight, telephone-based weight loss support, provided using an existing 6-month weight management and healthy lifestyle service did not reduce knee pain intensity or weight, compared with usual care. Trial registration number: ACTRN12615000490572
KW - Knee
KW - Obesity
KW - Osteoarthritis
KW - Randomised controlled trial
KW - Telephone
KW - Weight loss
UR - http://www.scopus.com/inward/record.url?scp=85040910168&partnerID=8YFLogxK
U2 - 10.1016/j.joca.2018.01.003
DO - 10.1016/j.joca.2018.01.003
M3 - Article
C2 - 29330101
AN - SCOPUS:85040910168
VL - 26
SP - 485
EP - 494
JO - Osteoarthritis and Cartilage
JF - Osteoarthritis and Cartilage
SN - 1063-4584
IS - 4
ER -