Telomere dynamics: The influence of folate and DNA methylation

Carly Moores, Michael Fenech, Nathan O'Callaghan

    Research output: Contribution to journalArticle

    28 Citations (Scopus)

    Abstract

    Since the suggestion of their existence, a wealth of literature on telomere biology has emerged aimed at solving the DNA end-underreplication problem identified by Olovnikov in 1971. Telomere shortening/dysfunction is now recognized as increasing degenerative disease risk. Recent studies have suggested that both dietary patterns and individual micronutrients-including folate-can influence telomere length and function. Folate is an important dietary vitamin required for DNA synthesis, repair, and one-carbon metabolism within the cell. However, the potential mechanisms by which folate deficiency directly or indirectly affects telomere biology has not yet been reviewed comprehensively. The present review summarizes recent published knowledge and identifies the residual knowledge gaps. Specifically, this review addresses whether it is plausible that folate deficiency may (1) cause accelerated telomere shortening, (2) intrinsically affect telomere function, and/or (3) cause increased telomere-end fusions and subsequent breakage-fusion-bridge cycles in the cell.

    Original languageEnglish
    Pages (from-to)76-88
    Number of pages13
    JournalAnnals of the New York Academy of Sciences
    Volume1229
    Issue number1
    DOIs
    Publication statusPublished - 2011

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