TY - JOUR
T1 - Temporal patterns of cancer burden in Asia, 1990–2019
T2 - a systematic examination for the Global Burden of Disease 2019 study
AU - GBD 2019 Asia and All Cancers Collaborators
AU - Sharma, Rajesh
AU - Abbastabar, Hedayat
AU - Abdulah, Deldar Morad
AU - Abidi, Hassan
AU - Abolhassani, Hassan
AU - Abrehdari-Tafreshi, Zahra
AU - Absalan, Abdorrahim
AU - Ali, Hiwa Abubaker
AU - Abu-Gharbieh, Eman
AU - Acuna, Juan Manuel
AU - Adib, Nasrin
AU - Adnani, Qorinah Estiningtyas Sakilah
AU - Aghaei, Abbas
AU - Ahmad, Aqeel
AU - Ahmad, Sajjad
AU - Ahmadi, Ali
AU - Ahmadi, Sepideh
AU - Ahmed, Luai A.
AU - Ajami, Marjan
AU - Al Hamad, Hanadi
AU - Al Hasan, Syed Mahfuz
AU - Alanezi, Fahad Mashhour
AU - Al-Gheethi, Adel Ali Saeed
AU - Al-Hanawi, Mohammed Khaled
AU - Ali, Abid
AU - Ali, Beriwan Abdulqadir
AU - Alimohamadi, Yousef
AU - Aljunid, Syed Mohamed
AU - Al-Maweri, Sadeq Ali Ali
AU - Alqahatni, Saleh A.
AU - AlQudah, Mohammad
AU - Al-Raddadi, Rajaa M.
AU - Al-Tammemi, Ala'a B.
AU - Ansari-Moghaddam, Alireza
AU - Anwar, Sumadi Lukman
AU - Anwer, Razique
AU - Aqeel, Muhammad
AU - Arabloo, Jalal
AU - Arab-Zozani, Morteza
AU - Ariffin, Hany
AU - Al Artaman, Artaman
AU - Arulappan, Judie
AU - Ashraf, Tahira
AU - Askari, Elaheh
AU - Athar, Mohammad
AU - Atout, Maha Moh d.Wahbi
AU - Azadnajafabad, Sina
AU - Badar, Muhammad
AU - Badiye, Ashish D.
AU - Baghcheghi, Nayereh
AU - Bagherieh, Sara
AU - Bai, Ruhai
AU - Bajbouj, Khuloud
AU - Baliga, Shrikala
AU - Bardhan, Mainak
AU - Bashiri, Azadeh
AU - Baskaran, Pritish
AU - Basu, Saurav
AU - Belgaumi, Uzma Iqbal
AU - Bermudez, Amiel Nazer C.
AU - Bhandari, Bharti
AU - Bhardwaj, Nikha
AU - Bhat, Ajay Nagesh
AU - Bitaraf, Saeid
AU - Boloor, Archith
AU - Hashemi, Milad Bonakdar
AU - Butt, Zahid A.
AU - Chadwick, Joshua
AU - Chan, Jeffrey Shi Kai
AU - Chattu, Vijay Kumar
AU - Chaturvedi, Pankaj
AU - Cho, William C.S.
AU - Darwesh, Aso Mohammad
AU - Dash, Nihar Ranjan
AU - Dehghan, Amin
AU - Dhali, Arkadeep
AU - Dianatinasab, Mostafa
AU - Dibas, Mahmoud
AU - Dixit, Abhinav
AU - Dixit, Shilpi Gupta
AU - Dorostkar, Fariba
AU - Dsouza, Haneil Larson
AU - Elbarazi, Iffat
AU - Elemam, Noha Mousaad
AU - El-Huneidi, Waseem
AU - Elkord, Eyad
AU - Elmeligy, Omar Abdelsadek Abdou
AU - Emamian, Mohammad Hassan
AU - Erkhembayar, Ryenchindorj
AU - Ezzeddini, Rana
AU - Fadoo, Zehra
AU - Faiz, Razana
AU - Fakhradiyev, Ildar Ravisovich
AU - Fallahzadeh, Aida
AU - Faris, Moez Al Islam Ezzat Mahmoud
AU - Farrokhpour, Hossein
AU - Fatehizadeh, Ali
AU - Fattahi, Hamed
AU - Fekadu, Ginenus
AU - Fukumoto, Takeshi
AU - Gaidhane, Abhay Motiramji
AU - Galehdar, Nasrin
AU - Garg, Priyanka
AU - Ghadirian, Fataneh
AU - Ghafourifard, Mansour
AU - Ghasemi, Mohammad Reza
AU - Nour, Mohammad Ghasemi
AU - Ghassemi, Fariba
AU - Gholamalizadeh, Maryam
AU - Gholamian, Asadollah
AU - Ghotbi, Elena
AU - Golechha, Mahaveer
AU - Goleij, Pouya
AU - Goyal, Sahil
AU - Gubari, Mohammed Ibrahim Mohialdeen
AU - Gunasekera, D. Sanjeeva
AU - Gunawardane, Damitha Asanga
AU - Gupta, Sapna
AU - Habibzadeh, Parham
AU - Boroojeni, Helia Sadat Haeri
AU - Halboub, Esam S.
AU - Hamadeh, Randah R.
AU - Hamoudi, Rifat
AU - Harorani, Mehdi
AU - Hasanian, Mohammad
AU - Hassan, Treska S.
AU - Hay, Simon I.
AU - Heidari, Mohammad
AU - Heidari-Foroozan, Mahsa
AU - Hessami, Kamran
AU - Hezam, Kamal
AU - Hiraike, Yuta
AU - Holla, Ramesh
AU - Hoseini, Mohammad
AU - Hossain, Md Mahbub
AU - Hossain, Sahadat
AU - Hsieh, Vivian Chia Rong
AU - Huang, Junjie
AU - Hussein, Nawfal R.
AU - Hwang, Bing Fang
AU - Iravanpour, Farideh
AU - Ismail, Nahlah Elkudssiah
AU - Iwagami, Masao
AU - Merin, Linda J.
AU - Jadidi-Niaragh, Farhad
AU - Jafarinia, Morteza
AU - Jahani, Mohammad Ali
AU - Jahrami, Haitham
AU - Jaiswal, Abhishek
AU - Jakovljevic, Mihajlo
AU - Jalili, Mahsa
AU - Jamshidi, Elham
AU - Jayarajah, Umesh
AU - Jayaram, Shubha
AU - Jha, Sweety Suman
AU - Jokar, Mohammad
AU - Joseph, Nitin
AU - Kabir, Ali
AU - Awal Kabir, Md
AU - Kadir, Dler Hussein
AU - Kakodkar, Pradnya Vishal
AU - Kalankesh, Laleh R.
AU - Kalankesh, Leila R.
AU - Kalhor, Rohollah
AU - Kaliyadan, Feroze
AU - Kamal, Vineet Kumar
AU - Kamal, Zul
AU - Kamath, Ashwin
AU - Kar, Sitanshu Sekhar
AU - Karimi, Hanie
AU - Kaur, Navjot
AU - Keikavoosi-Arani, Leila
AU - Keykhaei, Mohammad
AU - Khader, Yousef Saleh
AU - Khajuria, Himanshu
AU - Khan, Ejaz Ahmad
AU - Khan, M. Nuruzzaman
AU - Khan, Maseer
AU - Khan, Moien A.B.
AU - Khan, Yusra H.
AU - Khanmohammadi, Shaghayegh
AU - Khatatbeh, Moawiah Mohammad
AU - Khateri, Sorour
AU - Khayamzadeh, Maryam
AU - Kashani, Hamid Reza Khayat
AU - Kim, Min Seo
AU - Kompani, Farzad
AU - Koohestani, Hamid Reza
AU - Laxminarayana, Sindhura Lakshmi Koulmane
AU - Krishan, Kewal
AU - Kumar, Narinder
AU - Kumar, Naveen
AU - Kutluk, Tezer
AU - Kuttikkattu, Ambily
AU - Lai, Daphne Teck Ching
AU - Lal, Dharmesh Kumar
AU - Lami, Faris Hasan
AU - Lasrado, Savita
AU - Lee, Sang Woong
AU - Lee, Seung Won
AU - Lee, Yeong Yeh
AU - Lee, Yo Han
AU - Leong, Elvynna
AU - Li, Ming Chieh
AU - Liu, Jue
AU - Madadizadeh, Farzan
AU - Mafi, Ahmad R.
AU - Mahjoub, Soleiman
AU - Malekzadeh, Reza
AU - Malik, Ahmad Azam
AU - Malik, Iram
AU - Mallhi, Tauqeer Hussain
AU - Mansournia, Mohammad Ali
AU - Martini, Santi
AU - Mathews, Elezebeth
AU - Mathur, Manu Raj
AU - Meena, Jitendra Kumar
AU - Menezes, Ritesh G.
AU - Mirfakhraie, Reza
AU - Mirinezhad, Seyed Kazem
AU - Mirza-Aghazadeh-Attari, Mohammad
AU - Mithra, Prasanna
AU - Mohamadkhani, Ashraf
AU - Mohammadi, Soheil
AU - Mohammadzadeh, Maryam
AU - Mohan, Syam
AU - Mokdad, Ali H.
AU - Al Montasir, Ahmed
AU - Montazeri, Fateme
AU - Moradi, Maryam
AU - Sarabi, Mostafa Moradi
AU - Moradpour, Farhad
AU - Moradzadeh, Mali
AU - Moraga, Paula
AU - Mosapour, Abbas
AU - Motaghinejad, Majid
AU - Mubarik, Sumaira
AU - Muhammad, Jibran Sualeh
AU - Murray, Christopher J.L.
AU - Nagarajan, Ahamarshan Jayaraman
AU - Naghavi, Mohsen
AU - Nargus, Shumaila
AU - Natto, Zuhair S.
AU - Nayak, Biswa Prakash
AU - Nejadghaderi, Seyed Aria
AU - Nguyen, Phuong The
AU - Niazi, Robina Khan
AU - Noroozi, Nafise
AU - Okati-Aliabad, Hassan
AU - Shorofi, Seyed Afshin
PY - 2024/2
Y1 - 2024/2
N2 - Background: Cancers represent a challenging public health threat in Asia. This study examines the temporal patterns of incidence, mortality, disability and risk factors of 29 cancers in Asia in the last three decades. Methods: The age, sex and year-wise estimates of incidence, mortality, and disability-adjusted life years (DALYs) of 29 cancers for 49 Asian countries from 1990 through 2019 were generated as a part of the Global Burden of Disease, Injuries and Risk Factors 2019 study. Besides incidence, mortality and DALYs, we also examined the cancer burden measured in terms of DALYs and deaths attributable to risk factors, which had evidence of causation with different cancers. The development status of countries was measured using the socio-demographic index. Decomposition analysis was performed to gauge the change in cancer incidence between 1990 and 2019 due to population growth, aging and age-specific incidence rates. Findings: All cancers combined claimed an estimated 5.6 million [95% uncertainty interval, 5.1–6.0 million] lives in Asia with 9.4 million [8.6–10.2 million] incident cases and 144.7 million [132.7–156.5 million] DALYs in 2019. The age-standardized incidence rate (ASIR) of all cancers combined in Asia was 197.6/100,000 [181.0–214.4] in 2019, varying from 99.2/100,000 [76.1–126.0] in Bangladesh to 330.5/100,000 [298.5–365.8] in Cyprus. The age-standardized mortality rate (ASMR) was 120.6/100,000 [110.1–130.7] in 2019, varying 4-folds across countries from 71.0/100,000 [59.9–83.5] in Kuwait to 284.2/100,000 [229.2–352.3] in Mongolia. The age-standardized DALYs rate was 2970.5/100,000 [2722.6–3206.5] in 2019, varying from 1578.0/100,000 [1341.2–1847.0] in Kuwait to 6574.4/100,000 [5141.7–8333.0] in Mongolia. Between 1990 and 2019, deaths due to 17 of the 29 cancers either doubled or more, and 20 of the 29 cancers underwent an increase of 150% or more in terms of new cases. Tracheal, bronchus, and lung cancer (both sexes), breast cancer (among females), colon and rectum cancer (both sexes), stomach cancer (both sexes) and prostate cancer (among males) were among top-5 cancers in most Asian countries in terms of ASIR and ASMR in 2019 and cancers of liver, stomach, hodgkin lymphoma and esophageal cancer posted the most significant decreases in age-standardized rates between 1990 and 2019. Among the modifiable risk factors, smoking, alcohol use, ambient particulate matter (PM) pollution and unsafe sex remained the dominant risk factors between 1990 and 2019. Cancer DALYs due to ambient PM pollution, high body mass index and fasting plasma glucose has increased most notably between 1990 and 2019. Interpretation: With growing incidence, cancer has become more significant public health threat in Asia, demanding urgent policy attention and guidance. Its heightened risk calls for increased cancer awareness, preventive measures, affordable early-stage detection, and cost-effective therapeutics in Asia. The current study can serve as a useful resource for policymakers and researchers in Asia for devising interventions for cancer management and control. Funding: The GBD study is funded by the Bill and Melinda Gates Foundation.
AB - Background: Cancers represent a challenging public health threat in Asia. This study examines the temporal patterns of incidence, mortality, disability and risk factors of 29 cancers in Asia in the last three decades. Methods: The age, sex and year-wise estimates of incidence, mortality, and disability-adjusted life years (DALYs) of 29 cancers for 49 Asian countries from 1990 through 2019 were generated as a part of the Global Burden of Disease, Injuries and Risk Factors 2019 study. Besides incidence, mortality and DALYs, we also examined the cancer burden measured in terms of DALYs and deaths attributable to risk factors, which had evidence of causation with different cancers. The development status of countries was measured using the socio-demographic index. Decomposition analysis was performed to gauge the change in cancer incidence between 1990 and 2019 due to population growth, aging and age-specific incidence rates. Findings: All cancers combined claimed an estimated 5.6 million [95% uncertainty interval, 5.1–6.0 million] lives in Asia with 9.4 million [8.6–10.2 million] incident cases and 144.7 million [132.7–156.5 million] DALYs in 2019. The age-standardized incidence rate (ASIR) of all cancers combined in Asia was 197.6/100,000 [181.0–214.4] in 2019, varying from 99.2/100,000 [76.1–126.0] in Bangladesh to 330.5/100,000 [298.5–365.8] in Cyprus. The age-standardized mortality rate (ASMR) was 120.6/100,000 [110.1–130.7] in 2019, varying 4-folds across countries from 71.0/100,000 [59.9–83.5] in Kuwait to 284.2/100,000 [229.2–352.3] in Mongolia. The age-standardized DALYs rate was 2970.5/100,000 [2722.6–3206.5] in 2019, varying from 1578.0/100,000 [1341.2–1847.0] in Kuwait to 6574.4/100,000 [5141.7–8333.0] in Mongolia. Between 1990 and 2019, deaths due to 17 of the 29 cancers either doubled or more, and 20 of the 29 cancers underwent an increase of 150% or more in terms of new cases. Tracheal, bronchus, and lung cancer (both sexes), breast cancer (among females), colon and rectum cancer (both sexes), stomach cancer (both sexes) and prostate cancer (among males) were among top-5 cancers in most Asian countries in terms of ASIR and ASMR in 2019 and cancers of liver, stomach, hodgkin lymphoma and esophageal cancer posted the most significant decreases in age-standardized rates between 1990 and 2019. Among the modifiable risk factors, smoking, alcohol use, ambient particulate matter (PM) pollution and unsafe sex remained the dominant risk factors between 1990 and 2019. Cancer DALYs due to ambient PM pollution, high body mass index and fasting plasma glucose has increased most notably between 1990 and 2019. Interpretation: With growing incidence, cancer has become more significant public health threat in Asia, demanding urgent policy attention and guidance. Its heightened risk calls for increased cancer awareness, preventive measures, affordable early-stage detection, and cost-effective therapeutics in Asia. The current study can serve as a useful resource for policymakers and researchers in Asia for devising interventions for cancer management and control. Funding: The GBD study is funded by the Bill and Melinda Gates Foundation.
KW - Asia
KW - Cancer burden
KW - Disability adjusted life years
KW - Global burden of disease
KW - Incidence
KW - Mortality
UR - http://www.scopus.com/inward/record.url?scp=85182411899&partnerID=8YFLogxK
U2 - 10.1016/j.lansea.2023.100333
DO - 10.1016/j.lansea.2023.100333
M3 - Article
AN - SCOPUS:85182411899
SN - 2772-3682
VL - 21
JO - The Lancet Regional Health - Southeast Asia
JF - The Lancet Regional Health - Southeast Asia
M1 - 100333
ER -