Termination of respiratory events with and without cortical arousal in obstructive sleep apnea

Amy S. Jordan, Danny J. Eckert, Andrew Wellman, John A. Trinder, Atul Malhotra, David P. White

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Rationale: A total of 20-30% of respiratory events in obstructive sleep apnea are terminated without clear arousal. Arousals are thought to predispose to further events by promoting hyperventilation, hypocapnia, and upper-airway dilator muscle hypotonia. Therefore, events terminated without arousal may promote stable breathing. Objectives: To compare physiologic changes at respiratory event termination with American Sleep Disorders Association (ASDA) Arousal to No Arousal, and determine whether secondary respiratory events are less common and have higher dilator muscle activity after No Arousal compared with ASDA Arousal. Methods: Patients with obstructive sleep apnea wore sleep staging, genioglossus (EMG GG), and tensor palatini (EMG TP) electrodes plus a nasal mask and pneumotachograph. During stable sleep, continuous positive airway pressure (CPAP) was lowered for 3-minute periods to induce respiratory events. Physiologic variables were compared between events terminated with (1) ASDA Arousal, (2) No Arousal, or (3) sudden CPAP increase (CPAPinc, control). Measurements and Main Results: Sixteen subjects had adequate data. EMG GG, EMG TP, and heart rate increased after ASDA Arousal (340 ± 57%, 215 ± 28%, and 110.7 ± 2.3%) and No Arousal (185 ± 32%, 167 ± 15%, and 108.5 ± 1.6%) but not CPAPinc (90 ± 10%, 94 ± 11%, and 102.1 ± 1%). Ventilation increased more after ASDA Arousal than No Arousal and CPAPinc, but not after accounting for the severity of respiratory event. Fewer No Arousals were followed by secondary events than ASDA Arousals. However, low dilator muscle activity did not occur after ASDA Arousal or No Arousal (EMG GGrose from 75 ± 5 to 125 ± 7%)and secondary events were less severe than initial events (ventilation rose 4 ± 0.4 to 5.5 ± 0.51 L/min). Conclusions: Respiratory events that were terminated with ASDA Arousal were more severely flow-limited, had enhanced hyperventilation after event termination, and were more often followed by secondary events than No arousal. However, secondary events were not associated with low dilator muscle activity and airflow was improved after both No Arousal and ASDA Arousal.

Original languageEnglish
Pages (from-to)1183-1191
Number of pages9
JournalAmerican journal of respiratory and critical care medicine
Volume184
Issue number10
DOIs
Publication statusPublished - 15 Nov 2011
Externally publishedYes

Keywords

  • pharyngeal muscle activity
  • upper airway obstruction
  • obstructive respiratory event
  • tensor palatini
  • genioglossus
  • Tensor palatini
  • Genioglossus
  • Obstructive respiratory event
  • Upper airway obstruction
  • Pharyngeal muscle activity

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