The action of the benzopyrones on an experimental model of lymphoedema: A contribution to their mode of action

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Abstract

A number of preparations containing benzopyrones are used clinically as a therapy for lymphedema; however, their exact mode of action is not well known. This work presents evidence which indicates that in rats, as in the treatment of thermally induced edemas, the benzopyrones work by enhancing the lysis of the accumulated proteins. This is evidenced by reduced levels of total protein in the extracellular compartment of the skin, while peptides and amino acids were increased in the serum at 6 and 12 h respectively after the drug's administration. Distinct increases in peptides and amino acids at other times in the serum and skin were not found, which is attributed to their rapid incorporation into the large number of maturing phagocytes which enter the lymphedematous tissues. Likewise, protease activity levels were not elevated as expected. This possibly was the consequence of a number of factors including serum deactivation, inhibition of release and membrane stabilization.

Original languageEnglish
Pages (from-to)713-721
Number of pages9
JournalBritish Journal of Experimental Pathology
Volume57
Issue number6
Publication statusPublished - 1976
Externally publishedYes

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