Abstract
The actions of 2-hydroxy-saclofen (2-OH-S), a recently developed analog of baclofen, were studied at presynaptic GABAB receptors in the rat hippocampal slice. Baclofen (0.5-20 μM) reduces the amplitude of excitatory postsynaptic potentials (EPSPs) recorded from hippocampal CA1 pyramidal neurons. In the presence of 200-500 μM 2-OH-S, the synaptic depressant action of baclofen is significantly reduced. These data show that 2-OH-S is an effective antagonist at presynaptic GABAB receptors on excitatory terminals in the hippocampus.
Original language | English |
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Pages (from-to) | 272-276 |
Number of pages | 5 |
Journal | Neuroscience Letters |
Volume | 119 |
Issue number | 2 |
DOIs | |
Publication status | Published - 13 Nov 1990 |
Keywords
- 2-Hydroxysaclofen
- GABA receptor
- Hippocampus
- Rat