The actions of 2-hydroxy-saclofen at presynaptic GABAB receptors in the rat hippocampus

Neil L Harrison, David M Lovinger, Nevin A Lambert, Timothy J Teyler, Rolf Prager, Jennifer Ong, David I B Kerr

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    41 Citations (Scopus)

    Abstract

    The actions of 2-hydroxy-saclofen (2-OH-S), a recently developed analog of baclofen, were studied at presynaptic GABAB receptors in the rat hippocampal slice. Baclofen (0.5-20 μM) reduces the amplitude of excitatory postsynaptic potentials (EPSPs) recorded from hippocampal CA1 pyramidal neurons. In the presence of 200-500 μM 2-OH-S, the synaptic depressant action of baclofen is significantly reduced. These data show that 2-OH-S is an effective antagonist at presynaptic GABAB receptors on excitatory terminals in the hippocampus.

    Original languageEnglish
    Pages (from-to)272-276
    Number of pages5
    JournalNeuroscience Letters
    Volume119
    Issue number2
    DOIs
    Publication statusPublished - 13 Nov 1990

    Keywords

    • 2-Hydroxysaclofen
    • GABA receptor
    • Hippocampus
    • Rat

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