The Activated Partial Thromboplastin Time

Jeffrey L. Chin, J. Hirsh, A. S. Gallus

Research output: Contribution to journalLetterpeer-review

9 Citations (Scopus)


To the Editor: In a recent article in the Journal by Basu et al. the usefulness of monitoring heparin therapy by the activated partial thromboplastin time (APTT) is emphasized.1 The authors recommend that patients with venous thromboembolism be given doses of heparin that prolong the APTT to between 1.5 and 2.5 times control levels. However, Soloway et al. emphasize that “… optimal ranges of heparin anticoagulation must be defined in terms of the products used in the performance of APTT's, and that ranges established with one product cannot be interchanged when using another manufacturer's reagents.”2 Moreover, Lenahan and Phillips have.

Original languageEnglish
Pages (from-to)1410
Number of pages1
JournalNew England Journal of Medicine
Issue number26
Publication statusPublished - 28 Jun 1973


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