The "Albumin Effect" and in Vitro-in Vivo Extrapolation: Sequestration of Long-Chain Unsaturated Fatty Acids Enhances Phenytoin Hydroxylation by Human Liver Microsomal and Recombinant Cytochrome P450 2C9

Andrew Rowland; David Elliot; Kathleen Knights; Peter Mackenzie; John Miners

The "Albumin Effect" and in Vitro-in Vivo Extrapolation: Sequestration of Long-Chain Unsaturated Fatty Acids Enhances Phenytoin Hydroxylation by Human Liver Microsomal and Recombinant Cytochrome P450 2C9

Andrew Rowland, David Elliot, Kathleen Knights, Peter Mackenzie, John Miners

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

Original language	English
Pages (from-to)	870-877
Number of pages	8
Journal	Drug Metabolism and Disposition
Volume	36
Issue number	5
Publication status	Published - 2008

Cite this

@article{1510582260144a65bf88144596c0ba1a,

title = "The {"}Albumin Effect{"} and in Vitro-in Vivo Extrapolation: Sequestration of Long-Chain Unsaturated Fatty Acids Enhances Phenytoin Hydroxylation by Human Liver Microsomal and Recombinant Cytochrome P450 2C9",

author = "Andrew Rowland and David Elliot and Kathleen Knights and Peter Mackenzie and John Miners",

year = "2008",

language = "English",

volume = "36",

pages = "870--877",

journal = "Drug Metabolism and Disposition",

issn = "0090-9556",

publisher = "AMERICAN SOCIETY FOR PHARMACOLOGY EXPERIMENTAL THERAPEUTICS",

number = "5",

}

The "Albumin Effect" and in Vitro-in Vivo Extrapolation: Sequestration of Long-Chain Unsaturated Fatty Acids Enhances Phenytoin Hydroxylation by Human Liver Microsomal and Recombinant Cytochrome P450 2C9. / Rowland, Andrew; Elliot, David; Knights, Kathleen et al.

In: Drug Metabolism and Disposition, Vol. 36, No. 5, 2008, p. 870-877.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The "Albumin Effect" and in Vitro-in Vivo Extrapolation: Sequestration of Long-Chain Unsaturated Fatty Acids Enhances Phenytoin Hydroxylation by Human Liver Microsomal and Recombinant Cytochrome P450 2C9

AU - Rowland, Andrew

AU - Elliot, David

AU - Knights, Kathleen

AU - Mackenzie, Peter

AU - Miners, John

PY - 2008

Y1 - 2008

M3 - Article

VL - 36

SP - 870

EP - 877

JO - Drug Metabolism and Disposition

JF - Drug Metabolism and Disposition

SN - 0090-9556

IS - 5

ER -