The association between metabolic syndrome severity and oxidative stress induced by maximal exercise testing: a cross-sectional study

Alistair R. Mallard, Joyce S. Ramos, Llion A. Roberts, Christoph M. Centner, Robert G. Fassett, Jeff S. Coombes

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Oxidative stress (OS) has been implicated in the pathogenesis of metabolic syndrome (MetS). The acute change in OS biomarkers due to exercise, known as exercise-induced OS (EIOS), is postulated to be a more appropriate marker of OS compared to spot OS measures. These studies objectives were to investigate EIOS in participants with MetS and compare the associations between EIOS, spot OS measures and MetS severity. Methods: Sixty-three participants with MetS had MetS severity assessed using the MetS Z-score. Participants undertook a cardiorespiratory fitness test (VO2peak) to volitional exhaustion (∼8–12 minutes). Plasma OS (total F2-isoprostanes (IsoP), protein carbonyls (PCs)) and antioxidant (glutathione peroxidase (GPx), total antioxidant status (TAS)) biomarkers were measured from samples obtained before and five minutes post- (Formula presented.) O2peak test. Wilcoxon’s signed-rank tests were used to determine changes in OS markers. Results: There were no significant (p > 0.05) changes in OS or antioxidant biomarkers from pre- to post-exercise (median (interquartile range): IsoP –15.5 (–71.8 to 47.8) pg/mL; PC –0.01 (–0.16 to 0.13) nmol/mg protein; GPx 0.76 (–4.94 to 9.82) U/L, TAS 0.03 (0.00–0.05) mmol/L). Conclusions: A VO2peak test to exhaustion failed to induce OS in participants with MetS. There were no associations between MetS severity and spot OS or EIOS biomarkers.

Original languageEnglish
Pages (from-to)394-400
Number of pages7
JournalBiomarkers
Volume24
Issue number4
DOIs
Publication statusPublished - 9 Apr 2019

Keywords

  • antioxidants
  • cardiorespiratory fitness
  • exercise
  • F2-isoprostanes
  • protein carbonyls

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