The association of parental methylenetetrahydrofolate reductase polymorphisms (MTHFR 677C > T and 1298A > C) and fetal loss: a case–control study in South Australia

Britt J.P. Kos, Shalem Y. Leemaqz, Catherine D. McCormack, Prabha H. Andraweera, Denise L. Furness, Claire T. Roberts, Gustaaf A. Dekker

Research output: Contribution to journalArticle

Abstract

Objective: To determine the association between parental MTHFR 677C > T (RS1801133) and 1298A > C (RS1801131), and fetal loss (FL). Design: Case–control study. Setting: Department of Obstetrics and Gynecology, Lyell McEwin Hospital (LMH), and the Women’s and Children’s Hospital (WCH) in Adelaide, Australia. Patients: A total of 222 couples with FL and 988 couples with uncomplicated pregnancies. Measurements: The main outcomes were FL and hyperhomocysteinemia (HHcy). All couples were tested for MTHFR 677C > T and 1298A > C. Fasting homocysteine was measured in the women with FL. Results: The main finding was a significant difference between the FL group and controls in couples with ≥4 abnormal alleles compared to <4 [p=.0232, OR 1.9 (95% CI 1.1–3.3)]. None of the couples with FL had zero abnormal alleles (both parents 677CC/1298 AA). However, this was also rare amongst the controls. Maternal carriage of both 677C > T and the 1298A > C polymorphisms was similar between the FL group and controls. The prevalence of paternal 677TT/1298AA and 677CC/1298AC was significantly higher in the FL group compared with controls. HHcy was significantly more common in the FL group compared with controls. Conclusion: The presence of parental MTHFR 677C > T and 1298A > C is associated with FL. The association between maternal MTHFR genotypes with FL is less pronounced than in previously published articles investigating first trimester miscarriages. Maternal HHcy is a significant risk factor for FL.

Original languageEnglish
Pages (from-to)752-757
Number of pages6
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume33
Issue number5
DOIs
Publication statusPublished - 3 Mar 2020
Externally publishedYes

Keywords

  • Fetal loss
  • hyperhomocysteinemia
  • methylenetetrahydrofolate reductase
  • MTHFR
  • pregnancy loss

Fingerprint Dive into the research topics of 'The association of parental methylenetetrahydrofolate reductase polymorphisms (MTHFR 677C > T and 1298A > C) and fetal loss: a case–control study in South Australia'. Together they form a unique fingerprint.

  • Cite this