The Australian cerebral palsy research study - Protocol for a national collaborative study investigating genomic and clinical associations with cerebral pals

Michael O'Callaghan, Alastair MacLennan, Catherine Gibson, Gai McMichael, Eric Haan, Jessica Broadbent, Kevin Priest, Paul Goldwater, Gustaaf Dekker, Australian Collaborative Cereb

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    Aim: Previous studies have proposed a link between the presence of specific single nucleotide polymorphisms (SNPs) and cerebral palsy and the majority of these associations remain to be confirmed or rejected by prospective studies with sufficient statistical power. Prior studies have also given little attention to the interaction of genomic characteristics and clinical risk factors. Methods: This paper describes the design of a prospective case-control study to test these genetic associations in conjunction with more stringent data collection in respect to clinical features associated with pregnancy, particularly maternal infection. Here we consider the ethical requirements, our hypothesis that genetic susceptibility modifies the risk of cerebral palsy in the presence of perinatal environmental triggers, a priori primary and secondary aims, power calculations, participant recruitment strategies, data linkage, sampling methods of genetic material and subsequent SNP analysis, collection of clinical data and the proposed final statistical analysis.

    Original languageEnglish
    Pages (from-to)99-110
    Number of pages12
    JournalJournal of Paediatrics and Child Health
    Volume47
    Issue number3
    DOIs
    Publication statusPublished - 2011

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