The balance between human maternal plasma angiotensin II and angiotensin 1-7 levels in early gestation pregnancy is influenced by fetal sex

Shane D. Sykes, Kirsty G. Pringle, Ang Zhou, Gustaaf A. Dekker, Claire T. Roberts, Eugenie R. Lumbers

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Hypothesis: There are fetal sex-associated differences in the circulating maternal renin-angiotensin system (RAS) in early pregnancy. Methods: Plasma prorenin, angiotensin (Ang) II, Ang 1-7 and angiotensin-converting enzyme (ACE) concentrations were measured at 15 weeks' gestation in 131 women with uncomplicated pregnancies from the Adelaide SCOPE cohort. Uterine and umbilical artery Doppler sonography was performed at 20 weeks' gestation. Results: At 15 weeks, women bearing female fetuses had higher maternal Ang II concentrations (p = 0.017) and lower Ang 1-7 to Ang II ratios (p = 0.016) than women bearing males. In women with male fetuses, Ang II positively correlated with birth weight (p = 0.028) and prorenin negatively correlated with placental weight (p = 0.014). Female fetuses had higher umbilical artery resistance indices (p = 0.019) that were related to maternal prorenin concentrations (p = 0.007). Conclusions: In early human pregnancy, the maternal RAS is influenced by fetal sex. The lower Ang 1-7 to Ang II ratios in women with female fetuses may contribute to the lower maternal peripheral microvascular flow as described previously and the lack of any positive effect of Ang II on fetal growth, as seen in women with male fetuses.

Original languageEnglish
Pages (from-to)523-531
Number of pages9
JournalJRAAS - Journal of the Renin-Angiotensin-Aldosterone System
Volume15
Issue number4
DOIs
Publication statusPublished - 17 Dec 2014
Externally publishedYes

Bibliographical note

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm).

Keywords

  • angiotensin peptides
  • angiotensin-converting enzyme
  • Pregnancy
  • prorenin
  • sexual dimorphism

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