The benefits and limitations of expanded Y-chromosome short tandem repeat (Y-STR) loci

Julianne Henry; Claire Simon; Adrian Linacre

doi:10.1016/j.fsigss.2015.09.012

The benefits and limitations of expanded Y-chromosome short tandem repeat (Y-STR) loci

Julianne Henry, Claire Simon, Adrian Linacre

College of Science and Engineering

Research output: Contribution to conference › Paper › peer-review

3 Citations (Scopus)

Abstract

Recent advances in commercially available Y-chromosome short tandem repeat (Y-STR) profiling kits include the development of expanded locus sets and the inclusion of rapidly mutating (RM) Y-STR loci. Thermo Fisher Scientific recently released its Yfiler^® Plus (YF+) kit to the forensic market. Yfiler^® Plus has 27 loci, including 7 RM Y-STRs and full locus overlap with its predecessor AmpFlSTR® Yfiler™ (Yfiler). Forensic Science SA has been using Yfiler in routine forensic casework since 2007 but recently evaluated YF+ due to its apparent increased sensitivity and discrimination power. As with any transition to a new multiplex, there are benefits and limitations which need to be considered by each laboratory before implementation proceeds. Whilst there are a number of cost, profile interpretational and laboratory issues that need to be overcome, the benefits that YF+ provides over Yfiler will result in FSSA implementing this expanded multiplex for forensic casework.

Original language	English
Pages	e28-e30
DOIs	https://doi.org/10.1016/j.fsigss.2015.09.012
Publication status	Published - 2015
Event	26th International Society for Forensic Genetics Congress - Krakow, Poland Duration: 31 Aug 2015 → 5 Sep 2015

Conference

Conference	26th International Society for Forensic Genetics Congress
Country	Poland
City	Krakow
Period	31/08/15 → 5/09/15

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10.1016/j.fsigss.2015.09.012

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title = "The benefits and limitations of expanded Y-chromosome short tandem repeat (Y-STR) loci",

abstract = "Recent advances in commercially available Y-chromosome short tandem repeat (Y-STR) profiling kits include the development of expanded locus sets and the inclusion of rapidly mutating (RM) Y-STR loci. Thermo Fisher Scientific recently released its Yfiler{\textregistered} Plus (YF+) kit to the forensic market. Yfiler{\textregistered} Plus has 27 loci, including 7 RM Y-STRs and full locus overlap with its predecessor AmpFlSTR{\textregistered} Yfiler{\texttrademark} (Yfiler). Forensic Science SA has been using Yfiler in routine forensic casework since 2007 but recently evaluated YF+ due to its apparent increased sensitivity and discrimination power. As with any transition to a new multiplex, there are benefits and limitations which need to be considered by each laboratory before implementation proceeds. Whilst there are a number of cost, profile interpretational and laboratory issues that need to be overcome, the benefits that YF+ provides over Yfiler will result in FSSA implementing this expanded multiplex for forensic casework.",

author = "Julianne Henry and Claire Simon and Adrian Linacre",

year = "2015",

doi = "10.1016/j.fsigss.2015.09.012",

language = "English",

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note = "26th International Society for Forensic Genetics Congress ; Conference date: 31-08-2015 Through 05-09-2015",

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T1 - The benefits and limitations of expanded Y-chromosome short tandem repeat (Y-STR) loci

AU - Henry, Julianne

AU - Simon, Claire

AU - Linacre, Adrian

PY - 2015

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N2 - Recent advances in commercially available Y-chromosome short tandem repeat (Y-STR) profiling kits include the development of expanded locus sets and the inclusion of rapidly mutating (RM) Y-STR loci. Thermo Fisher Scientific recently released its Yfiler® Plus (YF+) kit to the forensic market. Yfiler® Plus has 27 loci, including 7 RM Y-STRs and full locus overlap with its predecessor AmpFlSTR® Yfiler™ (Yfiler). Forensic Science SA has been using Yfiler in routine forensic casework since 2007 but recently evaluated YF+ due to its apparent increased sensitivity and discrimination power. As with any transition to a new multiplex, there are benefits and limitations which need to be considered by each laboratory before implementation proceeds. Whilst there are a number of cost, profile interpretational and laboratory issues that need to be overcome, the benefits that YF+ provides over Yfiler will result in FSSA implementing this expanded multiplex for forensic casework.

AB - Recent advances in commercially available Y-chromosome short tandem repeat (Y-STR) profiling kits include the development of expanded locus sets and the inclusion of rapidly mutating (RM) Y-STR loci. Thermo Fisher Scientific recently released its Yfiler® Plus (YF+) kit to the forensic market. Yfiler® Plus has 27 loci, including 7 RM Y-STRs and full locus overlap with its predecessor AmpFlSTR® Yfiler™ (Yfiler). Forensic Science SA has been using Yfiler in routine forensic casework since 2007 but recently evaluated YF+ due to its apparent increased sensitivity and discrimination power. As with any transition to a new multiplex, there are benefits and limitations which need to be considered by each laboratory before implementation proceeds. Whilst there are a number of cost, profile interpretational and laboratory issues that need to be overcome, the benefits that YF+ provides over Yfiler will result in FSSA implementing this expanded multiplex for forensic casework.

U2 - 10.1016/j.fsigss.2015.09.012

DO - 10.1016/j.fsigss.2015.09.012

M3 - Paper

SP - e28-e30

T2 - 26th International Society for Forensic Genetics Congress

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