The benefits and limitations of expanded Y-chromosome short tandem repeat (Y-STR) loci

Julianne Henry, Claire Simon, Adrian Linacre

Research output: Contribution to conferencePaper

3 Citations (Scopus)

Abstract

Recent advances in commercially available Y-chromosome short tandem repeat (Y-STR) profiling kits include the development of expanded locus sets and the inclusion of rapidly mutating (RM) Y-STR loci. Thermo Fisher Scientific recently released its Yfiler® Plus (YF+) kit to the forensic market. Yfiler® Plus has 27 loci, including 7 RM Y-STRs and full locus overlap with its predecessor AmpFlSTR® Yfiler™ (Yfiler). Forensic Science SA has been using Yfiler in routine forensic casework since 2007 but recently evaluated YF+ due to its apparent increased sensitivity and discrimination power. As with any transition to a new multiplex, there are benefits and limitations which need to be considered by each laboratory before implementation proceeds. Whilst there are a number of cost, profile interpretational and laboratory issues that need to be overcome, the benefits that YF+ provides over Yfiler will result in FSSA implementing this expanded multiplex for forensic casework.

Original languageEnglish
Pagese28-e30
DOIs
Publication statusPublished - 2015
Event26th International Society for Forensic Genetics Congress - Krakow, Poland
Duration: 31 Aug 20155 Sep 2015

Conference

Conference26th International Society for Forensic Genetics Congress
CountryPoland
CityKrakow
Period31/08/155/09/15

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    Henry, J., Simon, C., & Linacre, A. (2015). The benefits and limitations of expanded Y-chromosome short tandem repeat (Y-STR) loci. e28-e30. Paper presented at 26th International Society for Forensic Genetics Congress, Krakow, Poland. https://doi.org/10.1016/j.fsigss.2015.09.012