The binding of 3 14C coumarin to serum proteins in the rat: a comparison between in vitro and in vivo estimations

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Like other benzo-pyrones, coumarin shows serum protein binding. Under in vitro conditions irrespective of the dose which ranged from 50-3.31 μgm/ml binding remained at ∞40%. After i.v. administration an average of 4.6% of the injected dose remained in the vascular system, of which an average of 37% was bound to serum albumins. In case of i.p. administration an average of 4% of the injected dose entered the vascular system of which an average of 36.5% was in the bound form.

Original languageEnglish
Pages (from-to)175-179
Number of pages5
JournalExperimental Pathology
Volume13
Issue number2-3
DOIs
Publication statusPublished - 1977
Externally publishedYes

Fingerprint Dive into the research topics of 'The binding of 3 <sup>14</sup>C coumarin to serum proteins in the rat: a comparison between in vitro and in vivo estimations'. Together they form a unique fingerprint.

  • Cite this