The Bipolar Association Case-Control Study (BACCS) and meta-analysis: No association with the 5,10-methylenetetrahydrofolate reductase gene and bipolar disorder

Sarah Cohen-Woods, Ian Craig, Darya Gaysina, Joanna Gray, Cerisse Gunasinghe, Nick Craddock, Amanda Elkin, Lisa Jones, James Kennedy, Ania Korszun, Jo Knight, Michael Owen, Sagar Parikh, John Strauss, Abram Sterne, Ferderica Tozzi, Julia Perry, Pierandrea Muglia, John Vincent, Peter McGuffinAnne Farmer

    Research output: Contribution to journalReview article

    26 Citations (Scopus)

    Abstract

    Bipolar disorder (BD) is a complex genetic disease for which the underlying pathophysiology has yet to be fully explained. 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate-mediated one-carbon metabolism and folate deficiency can be associated with psychiatric symptoms. A single base variant in MTHFR gene (C677T) results in the production of amildly dysfunctional thermolabile enzyme and has recently been implicated in BD. We conducted an association study of this polymorphism in 897 patients with bipolar I or bipolar II disorder, and 1,687 healthy control subjects. We found no evidence for genotypic or allelic association in this sample. We also performed ameta-analysis of our own, and all published data, and report no evidence for association. Our findings suggest that the MTHFR C677T polymorphism is not involved in the genetic etiology of clinically significant BD.

    Original languageEnglish
    Pages (from-to)1298-1304
    Number of pages7
    JournalAMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
    Volume153
    Issue number7
    DOIs
    Publication statusPublished - Oct 2010

    Keywords

    • Bipolar disorder
    • Genetics
    • Manic depression
    • Mood disorder
    • MTHFR

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  • Cite this

    Cohen-Woods, S., Craig, I., Gaysina, D., Gray, J., Gunasinghe, C., Craddock, N., Elkin, A., Jones, L., Kennedy, J., Korszun, A., Knight, J., Owen, M., Parikh, S., Strauss, J., Sterne, A., Tozzi, F., Perry, J., Muglia, P., Vincent, J., ... Farmer, A. (2010). The Bipolar Association Case-Control Study (BACCS) and meta-analysis: No association with the 5,10-methylenetetrahydrofolate reductase gene and bipolar disorder. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 153(7), 1298-1304. https://doi.org/10.1002/ajmg.b.31101