The BTB-ZF transcription factors

Owen M. Siggs, Bruce Beutler

Research output: Contribution to journalReview articlepeer-review

72 Citations (Scopus)


The BTB-ZF (broad-complex, tramtrack and bric-à-brac - zinc finger) proteins are encoded by at least 49 genes in mouse and man and commonly serve as sequence-specific silencers of gene expression. This review will focus on the known physiological functions of mammalian BTB-ZF proteins, which include essential roles in the development of the immune system. We discuss their function in terminally differentiated lymphocytes and the progenitors that give rise to them, their action in hematopoietic malignancy and roles beyond the immune system.

Original languageEnglish
Pages (from-to)3358-3369
Number of pages12
Issue number18
Publication statusPublished - 15 Sep 2012
Externally publishedYes


  • BTB
  • Hematopoiesis
  • Lymphoma
  • Lymphopoiesis
  • Zinc finger


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