The BTB-ZF transcription factors

Owen M. Siggs; Bruce Beutler

doi:10.4161/cc.21277

The BTB-ZF transcription factors

Owen M. Siggs, Bruce Beutler

Research output: Contribution to journal › Review article › peer-review

106 Citations (Scopus)

Abstract

The BTB-ZF (broad-complex, tramtrack and bric-à-brac - zinc finger) proteins are encoded by at least 49 genes in mouse and man and commonly serve as sequence-specific silencers of gene expression. This review will focus on the known physiological functions of mammalian BTB-ZF proteins, which include essential roles in the development of the immune system. We discuss their function in terminally differentiated lymphocytes and the progenitors that give rise to them, their action in hematopoietic malignancy and roles beyond the immune system.

Original language	English
Pages (from-to)	3358-3369
Number of pages	12
Journal	CELL CYCLE
Volume	11
Issue number	18
DOIs	https://doi.org/10.4161/cc.21277
Publication status	Published - 15 Sept 2012
Externally published	Yes

Keywords

BTB
Hematopoiesis
Lymphoma
Lymphopoiesis
Zinc finger

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/cc.21277Licence: In Copyright

Cite this

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KW - Lymphopoiesis

KW - Zinc finger

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The BTB-ZF transcription factors

Abstract

Keywords

UN SDGs

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