The calcium dependent endonuclease activity of isolated nuclear preparations. Relationships between its occurrence and the occurrence of other classes of enzymes found in nuclear preparations

Nuclear preparations have been examined for endonuclease activity. An endonuclease has been identified which requires both calcium and magnesium ions for activity and which is responsible for the calcium primed DNA synthesis observed in certain nuclear preparations. This enzyme increases during the later stages of liver regeneration. A magnesium requiring endonuclease has also been identified in certain nuclear preparations.