TY - JOUR
T1 - The catalyst-free syntheses of pyrazolo[3,4-b]quinolin-5-one and pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidin-5,7-dione derivatives by one-pot, three-component reactions
AU - Ezzati, Mahnaz
AU - Khalafy, Jabbar
AU - Marjani, Ahmad Poursattar
AU - Prager, Rolf H
PY - 2017/11/23
Y1 - 2017/11/23
N2 - Herein we report the syntheses of pyrazolo[3,4-b]quinolin-5-one and pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidin-5,7-dione derivatives by cyclocondensation of 1,3-diketones, 3-methyl-1-phenyl-1H-pyrazole-5-amine and arylglyoxals, under catalyst-free conditions in H2O/EtOH at reflux in 65–98% and 73–96% yields respectively. This protocol provides mild reaction conditions, good to high yields, non-catalytic, simple procedures and easy isolation of products to structurally diverse tricyclic pyrazolo[3,4-b]quinolin-5-one and pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidin-5,7-dione derivatives, which may have biological and pharmacological activities.
AB - Herein we report the syntheses of pyrazolo[3,4-b]quinolin-5-one and pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidin-5,7-dione derivatives by cyclocondensation of 1,3-diketones, 3-methyl-1-phenyl-1H-pyrazole-5-amine and arylglyoxals, under catalyst-free conditions in H2O/EtOH at reflux in 65–98% and 73–96% yields respectively. This protocol provides mild reaction conditions, good to high yields, non-catalytic, simple procedures and easy isolation of products to structurally diverse tricyclic pyrazolo[3,4-b]quinolin-5-one and pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidin-5,7-dione derivatives, which may have biological and pharmacological activities.
KW - Arylglyoxals
KW - Multi-component reactions
KW - One-pot
KW - Pyrazolo[3,4-b]quinolines
KW - Pyrido[2,3-d]pyrimidines
UR - http://www.scopus.com/inward/record.url?scp=85031399739&partnerID=8YFLogxK
U2 - 10.1016/j.tet.2017.10.004
DO - 10.1016/j.tet.2017.10.004
M3 - Article
AN - SCOPUS:85031399739
SN - 0040-4020
VL - 73
SP - 6587
EP - 6596
JO - Tetrahedron
JF - Tetrahedron
IS - 47
ER -